SBIR Phase I: Nanobiosensor for Cancer Marker Detection

这个小企业创新研究第一阶段项目旨在开发一种纳米生物传感器，用于光学检测，识别和量化重要的生物分子物种。该项目的重点是检测卵巢癌标志物。该传感器技术基于在光学基底上制造银纳米线阵列，然后对纳米线进行生物化学功能化以结合特定的生物分析物。使用超灵敏的光学探测技术，表面增强拉曼散射（Sers）来确定目标分析物的存在。该项目将寻求利用新的制造技术来建立一个多功能的生物传感平台，可以很容易地改变，以感测广泛的重要生物物种。第一阶段项目将设计纳米生物传感器来检测癌症标志物CA125的存在。 疾病的检测和诊断是纳米技术的主要潜在应用之一，这使得设备能够以与它们试图检测的生物物种和化学品相同的尺寸制造。第二阶段的工作将扩大癌症标志物检测的范围，并将传感平台纳入便携式，易于使用的医疗诊断工具。这项创新技术将应用于医学测试、环境监测以及化学和生物武器探测。

This Small Business Innovation Research Phase I project seeks to develop a nanobiosensor for optically detecting, discriminating, and quantifying important bio-molecular species. This project focuses on detection of ovarian cancer markers. The sensor technology is based on manufacturing arrays of silver nanowires on optical substrates and then bio-chemically functionalizing the nanowires to bind specific biological analytes. The presence of the targeted analyte is determined using the ultra-sensitive optical-probing technique, Surface Enhanced Raman Scattering (SERS). This project will seek to utilize novel manufacturing techniques to build a versatile bio-sensing platform that can be readily altered to sense a wide range of important biological species. The Phase I project will engineer the nanobiosensor to detect the presence of the cancer marker CA125. The detection and diagnosis of disease is one of the major potential applications of nanotechnology, which allows devices to be manufactured on the same size scale as the biological species and chemicals they seek to detect. Phase II work will expand the range of cancer marker detection and incorporate the sensing platform into a portable, easy to use medical diagnostic tool. This innovative technology will find applications in medical testing, environmental monitoring, and chemical and biological weapons detection.