CAREER: Ultrasensitive optical spectroscopy at a single particle level

摘要智力优势：本项目主要研究利用白光超连续介质光镊发展单粒子光谱学新技术。所提出的超连续统镊子不仅可以捕获粒子，还可以利用超连续统的宽带带宽对捕获的粒子进行宽带光学散射/吸收和相干反斯托克斯拉曼散射光谱。因此，捕获粒子的物理和化学特征（例如，大小、折射率、化学成分）都可以在原位探测。未来5年，PIs的研究将集中在以下三个方面：1)系统地研究超连续阱的性质和校准力；2)研究单个捕获粒子的宽带散射光谱；3)研究单个捕获粒子的宽带相干反斯托克斯拉曼散射光谱。更广泛的影响：拟议的研究可能会导致当前单粒子光谱和光镊子技术的重大进步，并有望对从工程和材料科学到生物学和生物医学的许多领域产生重大影响。此外，这个职业计划将提供一个很好的机会，让学生接触到广泛的光学光谱，并通过拟议的研究来训练他们，包括校准超连续统镊子的力，开发单粒子光谱的实验技术和系统，以及开发模拟工具来分析测量光谱。将努力促进妇女和少数民族学生参与研究。还将为高中教师和K-12学生提供教育机会。

Liu0547475AbstractIntellectual Merit:This CAREER program is focused on the development of a new single-particle optical spectroscopy technology using white light supercontinuum optical tweezers. The proposed supercontinuum tweezers can not only trap a particle but also perform broadband optical scattering/absorption and coherent anti-Stokes Raman scattering spectroscopy on the trapped particle, taking advantage of the broad bandwidth of the supercontinuum. Both the physical and chemical features (e.g., size, refractive index, chemical composition) of the trapped particle can therefore be probed in situ. Over the next five years, the PIs research will be focused on the following three tasks: 1) systematically investigate the properties of supercontinuum trap and calibrate the force; 2) investigate broadband optical scattering spectroscopy of a single trapped particle; and 3) investigate broadband coherent anti-Stokes Raman scattering spectroscopy of a single trapped particle.Broader Impact:The proposed research can potentially result in major advancement of the current single-particle spectroscopy and optical tweezers technologies, and is expected to have significant impact on many areas ranging from engineering and materials science to biology and biomedicine. In addition, this CAREER program will provide a great opportunity to expose students to the broad spectrum of optics and to train them through the proposed research which includes calibrating the force of supercontinuum tweezers, developing experimental techniques and systems for single particle spectroscopy, and developing simulation tools to analyze the measured spectra. Efforts will be made to foster woman and minority students to participate in the research. Education opportunities will also be provided for high school teachers and K-12 students.