Synthesis and function of heparin-containing block copolymers at interfaces

本提案描述了一种设计、制备和表征具有共价附着肝素的表面以创建抗血栓表面的策略。肝素是医院最常用的抗血栓药物之一，但长期服用会导致副作用。在拟议的研究中，肝素将使用表面移植的peo系留。PEO链是三嵌段共聚物PEO-PPO-PEO的组成部分，共价键连接到固体表面的PPO段位置。将使用低分子量肝素（LMWH），而不是未分离的游离肝素。目前用作植入物的生物材料表面不能有效抵抗血栓，肝素包被的生物材料在体内的表现与未肝素化的植入物没有什么不同。研究人员推测，造成这一结果的原因是对表面附着的肝素（肝素的空间和结构特征）控制不足。

0602718McGuireThis proposal describes a strategy to design, prepare, and characterize surfaces with covalently attached heparin to create thrombo-resistant surfaces. Heparin is among the most frequently anti-thrombotic drugs prescribed in hospitals, but long time administration results in side effects. In the proposed research, heparin will be tethered using surface grafted PEOs. PEO chains will be components of the tri-block copolymer PEO-PPO-PEO that will be covalently attached onto the solid surfaces at the position of the PPO segment. Low molecular weight heparin (LMWH) as opposed to unfractionated free heparin will be used. Biomaterials that are currently used as implants have surfaces that are not effectively thrombo-resistant, and heparin-coated biomaterials do not behave differently than unheparinized implants in vivo. The investigators hypothesize that the reason for this result is the inadequate control of surface attached heparin (spatial and structural character of heparin).