Development and Applications of Electron Transfer Initiated Cyclization Reactions

通过这个奖项，有机和大分子化学项目支持了匹兹堡大学化学系Paul Floreancig教授的工作。本研究将涉及电子转移引发的环化反应的发展和应用。在这个项目中，先前研究的结果将用于扩大这些反应在影响小分子和空间定向合成领域的范围。基于烯醇醚的新型电辅助基团的设计将扩大氧化裂解反应的应用。这些氧化碎片通过级联环化合成多环醚的效用将被检查。此外，将尝试将光氧化剂连接到氧化裂解部分，以用于光动力疗法和光化学表面修饰等潜在用途。从更广泛的意义上说，这些项目体现了物理有机化学在新反应设计中所起的重要作用。在这个项目中，学生将接触到纳米科学的研究目标。这个项目强调通过第一性原理进行机械分析，这对学生有很大的好处。

With this award, the Organic and Macromolecular Chemistry Program supports the work of Professor Paul Floreancig of the Chemistry Department at the University of Pittsburgh. This research will involve the development and applications of electron transfer initiated cyclization reactions. In this project the results from prior studies will be used to broaden the scope of these reactions in areas that impact small molecule and spatially directed synthesis. The applications of oxidative cleavage reactions will be expanded by designing new electroauxiliary groups based on enol ethers. The utility of these oxidative fragmentations for the synthesis of polycyclic ethers via cascade cyclizations will be examined. In addition, attempts will be made to tether photooxidants to oxidative cleavage moieties for potential use such as photodynamic therapies and photochemical surface modifications. In a broader sense, these projects exemplify the important role that physical organic chemistry can play in new reaction design. In this project, students will be exposed to research objectives in nanoscience. The emphasis on mechanistic analysis through first principles in this project imparts a significant benefit to students.