Detection of Decomposing Threat Agents

生产生物威胁剂的准备工作往往使用各种方法进行伪装，从加热到漂白剂处理，再到用普通的非致病性有机体淹没该地区。 检测的重点是天然物质的存在，如DNA或蛋白质。 将对各种试剂进行试剂和新方法，用于稳定细胞，以保存潜在的大分子分析物进行鉴定。已被热修饰的毒素的抗体识别结果将被表征和概括。从环境样本中可以看到一个相关的问题，其中热、阳光或高盐度等因素可能具有相同的效果。 对选择性试剂的进一步研究和特定特征的恢复将使新的法医分析方法的发展成为可能。在许多情况下，考虑修饰的确切机制可以为维持感兴趣的大分子的可检测水平提供线索。 注意到环境科学和威胁评估研究的广泛适用性和实用性。

The preparative work for producing biological threat agents is often disguised using a variety of methods, from heat, to treatment with bleach, to flooding the area with a common nonpathogenic organism. Detection has focused on the presence of native materials, such as DNA or proteins. A variety of agents will be subjected to reagents and new methods used to stabilize cells to preserve potential macromolecular analytes for identification. The antibody recognition results of toxins that have been heat-modified will be characterized and generalized. A related problem is seen from environmental samples, where agents such as heat, sunlight or high salinity may have the same effect. A further study on selective agents and the recovery of specific signatures will enable the development of new forensic assays. In many instances, consideration of the exact mechanism of modification can give clues for the maintenance of detectable levels of macromolecules of interest. The broad applicability and utility of the research in environmental science and threat assessment is noted.