Experimental pathology and in vivo-modelling of SARS-CoV-2 infection in different hamster species (Z01b)

对COVID-19致命后果的机制理解以及新疗法和疫苗的开发和测试在很大程度上取决于是否有适当的模型系统，该模型系统可以重现SARS-CoV-2感染的相关方面。由于人体组织在这方面的能力非常有限，而且目前的体外模型仍然无法完全模拟疾病的复杂性，因此动物模型对于实现这些目标仍然是不可或缺的。由于各种原因，一些仓鼠物种最近被确定为最有希望的活体模型。我们的目标是了解这些模型与人类COVID-19的异同，优化它们的应用，实现数字图像分析、组织库和存档材料的重复使用模式。遵循既定的3R原则，我们支持CRC-TR84联盟快速开发和安全测试新疗法和疫苗。

A mechanistic understanding of the lethal outcome of COVID-19 as well as the development and testing of novel therapies and vaccines are highly contingent upon the availability of an appropriate model system that allows to reproduce relevant aspects of SARS-CoV-2 infection. As human tissues are highly limited for this purpose and current alternative in vitro-models still fail to simulate the disease in its entire complexity, animal models are still indispensable for these goals. For various reasons, several hamster species have recently been established as the most promising in vivomodels. We here aim to understand these models in their similarities and differences to human COVID-19, optimize their applications and implement digital image analyses, tissue banking and repeated use modalities of archived material. Following established 3R principles, we support the CRC-TR84 consortium in the rapid development and safe testing of new therapies and vaccines.