SGER: Unsteady Fluid Mechanics of Nanoscale Vesicles of Lipid Bilayer, Fluid Membranes: Novel Drug Carriers

摘要提案编号：CTS-0631280主要研究者：Bobba，Kumar M.附属机构： 马萨诸塞大学阿默斯特分校提案标题：SGER：脂质双层纳米尺度囊泡的不稳定流体力学，流体膜：新型药物载体该提案已通过内部审查。本研究的目的是探索纳米尺度囊泡的流体动力学行为。学术价值：囊泡的化学、动力学、结构和材料特性以及它们在细胞过程中所起的重要运输作用使它们成为细胞生物学中的一个重要研究对象。本提案的主要目标是（a）开发基于连续流体力学的囊泡模型和（B）对流体膜囊泡的不稳定性进行系统和严格的理论和计算研究。一个统一的多尺度框架将被开发，其中的流体双层膜将被建模为一个二维曲面上的Navier-Stokes流体和周围的水将被建模为一个不可压缩的，Stokes流体的volume.Broader影响：除了其内在的科学利益，囊泡也可以用来建立生物机械控制药物输送，基因治疗等，因此是技术和实际的重要性。这项工作将提供研究生和本科生的研究机会，成果将纳入教学活动。

ABSTRACTProposal Number: CTS-0631280Principal Investigator: Bobba, Kumar M.Affiliation: University of Massachussetts AmherstProposal Title: SGER: Unsteady Fluid Mechanics of Nanoscale Vesicles of Lipid Bilayer, Fluid Membranes: Novel Drug Carriers This proposal has undergone internal review. The aim of the proposed exploratory research is to investigate behavior of nanoscale vesicle fluid dynamics.Intellectual Merit:The chemical, dynamic, structural and material properties of vesicles and the important transport role that they play in the cellular processes make them an object of central interest in cell biology. The primary objective of this proposal is (a) to develop good models for vesicles based on continuum fluid mechanics and (b) to do a systematic and rigorous theoretical and computational study of instabilities in vesicles of fluid membranes. A unified multiscale framework will be developed, wherein the fluid bilayer membrane will be modeled as a Navier-Stokes fluid on a two-dimensional curved surface and the surrounding water will be modeled as an incompressible, Stokesian fluid in a volume.Broader Impacts:Apart from their intrinsic scientific interest, vesicles can also be used to build biomachines for controlled drug delivery, gene therapy, etc. and hence are of technological and practical importance. The work will provide graduate and undergraduate research opportunities, and outcomes will be incorporated into teaching activities.