SGER Creating Catalytic Monodisperse Particles Using Microreactors

摘要建议编号：CTS-0647257主要研究人员：McQuade，D.Tyler隶属关系：康奈尔大学-EndowProposal标题：SGER：使用微反应器创建催化单分散粒子智力优点：合成分子使我们的生活更安全、更健康和更幸福。不幸的是，许多这些改善生活的化合物的合成都是困难和浪费的。该提案的目的是开发催化剂，使有机合成能够通过设计多个催化剂在单个容器或单个微反应器中顺序运行的过程来大大提高效率。这些多催化剂系统通过最大限度地增加在加工和分离中间体之前发生的化学转化的数量来提高效率。为了实现这一目标，需要开发新的材料来支撑均相催化剂。这项研究利用一个简单的微反应器来制备流动中的单分散硅氧烷，目的是加深对界面科学、聚合和流体动力学的理解。由于使用微反应器创造新材料是一个新的研究领域，对这一新兴领域的任何贡献都是一个重大的进步。广泛的影响：这项研究产生的独特材料将在许多学术领域以及工业中产生广泛的影响。这些材料将被用于促进更有效的药剂合成。这些材料还将用作新药开发、高温离子交换树脂以及其他需要高比表面积和高温稳定性的应用的载体。从这项研究中获得的知识也将有助于研究流体力学和材料的研究人员。拟议的研究将集中在微尺度系统中流动诱导弥散和自组织之间的相互作用。复杂的实验程序涉及国际和平研究所实验室提供的最先进的仪器。在未来，进行的测量将被用来挑战现有的模型，这些模型估计了三维混沌流动中颗粒迁移产生的浓度分布。这项工作将提供研究生和本科生的研究机会，结果将被纳入研究生水平的课程。

ABSTRACTProposal Number: CTS-0647257Principal Investigator: McQuade, D. TylerAffiliation: Cornell University - EndowProposal Title: SGER: Creating Catalytic Monodisperse Particles Using Microreactors Intellectual Merit:Synthetic molecules make our lives safer, healthier, and happier. Unfortunately, the synthesis of many of these life-improving compounds is difficult and wasteful. The aim of the proposal is to develop catalysts that will enable organic synthesis can be made substantially more efficient by designing processes in which multiple catalysts operate sequentially in a single vessel or in a single microreactor. These multi-catalyst systems increase efficiency by maximizing the number of chemical transformations that occur before work-up and isolation of intermediates. Realizing this goal requires the development of new materials for supporting homogeneous catalysts.This proposed research uses a simple microreactor to make monodisperse siloxanes in flow with the goal of a deeper understanding of interfacial science, polymerization, and fluid dynamics. Since the use of microreactors to create novel materials is a new field of research, any contribution to this emerging area is a significant advance forward.Broader Impacts:The unique materials created as a result of this research will have broad impact in a number of academic fields as well as in industry. These materials will be used to facilitate more efficient pharmaceutical agent synthesis. These materials will also be used as supports for new drug discovery, for high-temperature ion exchange resins, and for other applications where high surface area and high temperature stability are needed. The knowledge gained from this research will also aid researchers who study fluid dynamics and materials.The proposed research will focus of the interplay between flow-induced dispersion and self-organization in microscale systems. The complex experimental procedures involve state-of-the-art instruments available in the PI's laboratory. The measurements performed will, in the future, be used to challenge current models that estimate the concentration profiles resulting from particle migration in 3D chaotic flows. The work will provide graduate and undergraduate research opportunities, and outcomes will be incorporated into a graduate level course.