Study Bio-Deposition Induced Effect on Living Cells

这笔赠款为研究和开发科学和工程知识库提供资金，以研究生物沉积过程对活细胞的影响。项目活动包括：1)研究沉积活细胞和构建细胞嵌入结构的可行性；2)开发工程模型和多尺度建模方法来预测沉积过程中产生的机械力以及该过程和机械力对细胞生物学行为的影响；3)量化不同加工条件下细胞的生物反应及其活性、恢复、增殖和损伤。该项目可以导致开发新的技术和工具，以帮助发展新兴的基于细胞的生物制造，在治疗产品、生物芯片和生物传感器、诊断阵列、微流控系统和制药方法中得到广泛应用。如果成功，这项研究将促进工程学和生命科学的融合，并为生物和生命科学界提供可行的制造工具。该项目将积极吸引行业、政府和医疗机构参与。研究成果可应用于安全太空探索的任务、生物制造产品标准化的发展以及组织工程制造商未来细胞产品的优先顺序，从而对技术发展、经济增长和生活质量的提高产生广泛的影响。该项目还将开发一门新的跨学科课程，涵盖设计/制造、生物材料和生物/细胞力学，以培养下一代科学家和工程师。

This grant provides funding for research and development of a scientific and engineering knowledge base for studying the effect of bio-deposition process on living cells. The project activities involve: 1) studying the feasibility of depositing living cells and constructing cell-embedded structures; 2) developing an engineering model as well as a multi-scale modeling approach to predict the deposition process-induced mechanical forces and the effect of the process and the mechanical forces on the biological behavior of cells; and 3) quantifying the biological responses of cells, its viability, recovery, proliferation, and damage under varying processing conditions. This project can lead to developing new techniques and tools to help the advancement of emerging cell-based bio-fabrication for broad applications in therapeutic products, biochips and biosensors, diagnostic arrays, microfluidic systems, and pharmaceutical methods. If successful, this research will foster the convergence of engineering and life sciences, and provide viable manufacturing tools to biology and life sciences community. This project will actively engage industry, government and medical institution. The outcome of research can be applied to help the mission of safe exploration of space, the development of biofabrication product standardizations, and the prioritization of the future cell-based products for tissue engineering manufacturer, thus have broad impacts on the technological development, economic growth, and improvement of the quality of life. This project will also develop a new interdisciplinary course spanning Design/Manufacturing, Biomaterials, and Bio/Cell Mechanics to educate the next generation of scientists and engineers.