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A Dual Functional Freeform Microplasma Surface Patterning and Biologics Printing

双功能自由形态微等离子体表面图案化和生物制品印刷

基本信息

批准号：
1030520
负责人：
Wei Sun
金额：
$ 30万
依托单位：
Drexel University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-15 至 2014-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1030520&HistoricalAwards=false
关键词：
Dual Functional Freeform Microplasma Surface

项目摘要

The objective of this proposed research is to develop a new process to modify the surface function of a biological tissue scaffold. This novel printing process is a dual functional freeform microplasma surface patterning and biologics printing process which will produce maskless micro-size patterns as well as print biomolecules or living cells. Microplasma-induced surface property enhancement will be studied to identify its effect on biological activities such as cell attachment, proliferation and differentiation. An engineering model will predict the extent of surface functionalization generated with the plasma patterning process as a function of key process parameters. The proposed research integrates fundamental plasma science and freeform fabrication technology with life sciences and tissue engineering. If successful, this research will contribute to a novel and viable process that will operate at room temperature and atmospheric pressure to conduct maskless surface treatment and biologics printing. Manufacturing advantages include cost savings by way of fewer process steps, flexibility in material choices due to the more friendly process conditions and higher resolution printing of the molecules allowing for a wider window of applications. The ability to align living cells and proteins and to guide their functions will enable a fundamental and interdisciplinary research advance in scaffold-guided tissue engineering. In addition, the outcome of the research will also enable fabrication of cell-based therapeutic products, and create knowledge on developing a new generation of microplasma surface treatment techniques and biological printing systems. These will have a wide range of application in regenerative medicine, disease pathogenesis study, drug discovery and testing, and manufacturing cell/tissue-on-chips.

本研究的目的是开发一种新的工艺来修饰生物组织支架的表面功能。这种新型的打印工艺是一种具有双重功能的自由形状微等离子体表面图案和生物制品打印工艺，既可以打印生物分子或活细胞，也可以产生无掩模的微型图案。研究微等离子体诱导的表面特性增强，以确定其对细胞附着、增殖和分化等生物活性的影响。工程模型将预测等离子体图案化过程中产生的表面功能化程度作为关键工艺参数的函数。提出的研究将基础等离子体科学和自由形状制造技术与生命科学和组织工程相结合。如果成功，这项研究将有助于在室温和常压下进行无面罩表面处理和生物制品打印的新颖可行的工艺。制造优势包括通过更少的工艺步骤节省成本，由于更友好的工艺条件和更高分辨率的分子打印允许更宽的应用窗口，材料选择的灵活性。结合活细胞和蛋白质并指导其功能的能力将使支架引导组织工程的基础和跨学科研究取得进展。此外，研究结果还将使基于细胞的治疗产品的制造成为可能，并为开发新一代微等离子体表面处理技术和生物打印系统创造知识。这些将在再生医学、疾病发病机制研究、药物发现和测试以及制造细胞/组织芯片等方面有广泛的应用。