Development of s-Block Organometallic Reagents

该项目旨在实现s-嵌段有机金属配合物作为有机合成试剂的潜力。该项目的目标是利用这些金属在有效制备对合成化学家具有实用价值的有机分子中的效用。三个具体的研究领域将集中在：(i)开发碱土金属试剂来介导对映选择性去质子化反应，（ii）探索碱土电荷分离配合物的合成和合成用途，以及（iii）检查双有机金属配合物的制备和功能。所采用的策略将揭示有关所开发试剂的合成、结构、反应性、选择性和作用机制的基本方面。有了这个更新奖，有机和大分子化学项目支持了圣母大学化学和生物化学系的Kenneth W. Henderson教授的研究。该项目的主要目标是开发合成有机化学的新方法和试剂，利用更常见的含锂和含镁试剂的重同系物（如钙）的不寻常的反应性。反过来，所开发的方法可以应用于生物活性化合物的合成，用于对美国经济至关重要的领域，如农用化学品和制药工业。此外，所研究的金属通常价格低廉、无毒和无害环境，因此在工业环境中使用它们很有吸引力。

The project is directed towards realizing the potential of s-block organometallic complexes as reagents in organic synthesis. The goal of the project is to exploit the utility of these metals in the efficient preparation of organic molecules that are of practical value to synthetic chemists. Three specific areas of study will be focused upon: (i) developing alkaline earth metal reagents to mediate enantioselective deprotonation reactions, (ii) exploring the synthesis and synthetic utility of alkaline earth chargeseparated complexes, and (iii) examining the preparation and functionality of geminal diorganometallic complexes. The strategies adopted will uncover fundamental aspects concerning the synthesis, structures, reactivities, selectivities and mechanisms of action of the reagents developed. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Kenneth W. Henderson, of the Department of Chemistry and Biochemistry at the University of Notre Dame. The main goal of the project is to develop new methods and reagents for synthetic organic chemistry, exploiting the unusual reactivity of the heavier congeners (e.g., calcium) of the more commonly encountered lithium- and magnesium-containing reagents. In turn, the developed methods may be applied to the synthesis of biologically active compounds for use in areas of central importance to the US economy such as the agrochemical and pharmaceutical industries. In addition, the metals of interest are generally inexpensive, nontoxic and environmentally benign, which makes their use attractive in industrial settings.