The role of nitric oxide in modulating the hypoxic tumor response

肿瘤细胞通过激活低氧诱导因子1(HIF-1)对低氧做出反应，HIF-1控制代谢适应、血管生成和转移。侵袭宿主间质的巨噬细胞通过释放一氧化氮与肿瘤沟通。我们发现，一氧化氮可以调节细胞氧敏感过程，从而控制HIF-1依赖的低氧基因的激活。了解这种调节的机制将有助于更深入地了解肿瘤与宿主之间的通信，并将为靶向肿瘤细胞存活、缺氧和扩散的机制提供基础。

Tumor cells respond to hypoxia by activating hypoxia-inducible factor 1 (HIF-1), which controls metabolic adaptation, angiogenesis, and metastasis. Invading macrophages from the stroma of the host communicate with the tumor by releasing nitric oxide. We have found that nitric oxide can modulate the cellular oxygen-sensing process that controls HIF-1–dependent hypoxic gene activation. Understanding the mechanisms underlying this modulation would provide a deeper insight into the communication between tumor and host and would provide the basis for targeting the mechanisms by which tumor cells survive hypoxia and spread.