Detection of Decomposing Threat Agents

生产生物威胁剂的准备工作通常用各种方法进行伪装，从加热到用漂白剂处理，再到用一种常见的非致病性生物淹没该地区。检测的重点是天然物质的存在，比如DNA或蛋白质。各种各样的试剂和新方法将用于稳定细胞，以保存潜在的大分子分析物进行鉴定。热修饰毒素的抗体识别结果将被表征和推广。从环境样本中可以看到一个相关的问题，其中热、阳光或高盐度等因素可能具有相同的效果。对选择性药剂的进一步研究和特定特征的恢复将有助于发展新的法医分析。在许多情况下，考虑修饰的确切机制可以为维持感兴趣的大分子的可检测水平提供线索。指出了该研究在环境科学和威胁评估方面的广泛适用性和实用性。

The preparative work for producing biological threat agents is often disguised using a variety of methods, from heat, to treatment with bleach, to flooding the area with a common nonpathogenic organism. Detection has focused on the presence of native materials, such as DNA or proteins. A variety of agents will be subjected to reagents and new methods used to stabilize cells to preserve potential macromolecular analytes for identification. The antibody recognition results of toxins that have been heat-modified will be characterized and generalized. A related problem is seen from environmental samples, where agents such as heat, sunlight or high salinity may have the same effect. A further study on selective agents and the recovery of specific signatures will enable the development of new forensic assays. In many instances, consideration of the exact mechanism of modification can give clues for the maintenance of detectable levels of macromolecules of interest. The broad applicability and utility of the research in environmental science and threat assessment is noted.