Analysis of Peripheral MR Velocity Images for Direct Quantification of Pulsatile Pressures

这项建议的目标是开发一种基于相位对比(PC)的磁共振成像(MRI)技术来量化血流速度，从而利用压力-泊松方程通过量化的血流速度来计算血管内压。计算的压力可用于外周动脉疾病的无创性诊断。该项目将开发新的计算和成像方法，将其与基于磁共振的血管成像相结合，以实现对狭窄和/或闭塞动脉的几何和功能数据的非侵入性测量。所使用的研究方法将自动提取血管的几何形状，改进血流速度的获取，并使用磁共振技术优化压力机会的计算。开发的方法将在定常和脉动两种流动条件下，用几种几何模型进行验证。几何提取结果将与人工专家分析进行比较。速度和压力分布的量化将提供一种独特的非侵入性方法来评估和选择最能从血运重建过程中受益的患者。拟议的项目将在生物工程、医学成像和血管外科领域产生重要影响。此外，该项目为本科生和研究生的跨学科研究和教育机会提供了一个极好的工具。还计划开展一项针对少数群体的外联方案，并建立一个传播结果的网站。

0730467AminiThe goal of this proposal is to develop a Phase-Contrast (PC) based magnetic resonance imaging (MRI) technique to quantify blood flow velocity and thus to calculate intra-vascular pressure with quantified blood flow velocity by using the Pressure-Poisson Equation. The calculated pressure can be used for the noninvasive diagnosis of peripheral arterial disease. This project will develop new computational and imaging methods to be integrated with MR-based angiography to accomplish noninvasive measurement of geometric and functional data from stenotic and/or occluded arteries. The research methods used will automate the extraction of geometry of vessels, improve the acquisition of blood velocity, and optimize the calculation of pressure chances using MR techniques. The methods developed will be validated with phantoms of several geometries and under both steady and pulsatile flow conditions. Geometry extraction results will be compared against manual expert analysis. Quantification of velocity and pressure profiles would make available a unique noninvasive methodology for assessing and selecting the patients that can benefit the most from revascularization procedures.The proposed project can have an important impact in the fields of bioengineering, medical imaging, and vascular surgery. Furthermore, the project provides an excellent vehicle for interdisciplinary research and education opportunities of both undergraduate and graduate students. An outreach program for minorities and a web site for dissemination of the results are also planned.