Transfer ribonucleic acid (tRNA) synthetases as drug targets in Plasmodium falciparum

疟疾是一种主要的世界性传染病。这种疾病每年造成约200万人死亡，目前的药物由于寄生虫耐药性而越来越失败，对抑制不同靶点的新药产生了迫切需求。该研究员将研究一类新的寄生虫药物靶点，即转移核糖核酸（tRNA）合成酶，以寻找新的抑制剂。阻断这些酶的化合物可能会导致对抗疟疾的新药。

Malaria is a major worldwide infectious disease. The disease kills around 2 million people every year, and current drugs are increasingly failing due to parasite drug resistance, creating an urgent demand for new drugs, that inhibit different targets. The Fellow will study a new class of parasite drug targets, the transfer ribonucleic acid (tRNA) synthetase enzymes to find novel inhibitors. Compounds blocking these enzymes may lead to new drugs to combat malaria.