Special Thematic Program on "Mathematical and Quantitative Oncology"

癌症研究正处于数学和生物学知识相互作用的关键时刻，以了解癌症。癌症动力学的数学建模已经改进到这样一个程度，我们正处于一个数学模型可以用来探测癌症的病因和进展，并以知情的方式指导实验研究的点。多尺度数学建模技术和巨大的计算能力的结合，提供了通过遗传、亚细胞、细胞、组织和流行病学水平整合基本癌症生物学的可能性。这一跨学科领域的最新研究进展需要对年轻研究人员进行培训，以发展这些专业技能。这个为期两个月的研讨会计划将有助于在这一领域产生一个充满活力的年轻研究人员社区。这个研究项目的计划是组织多学科会议，集中讨论肿瘤学的主要突出问题。这一系列会议将结合三个主要研究所的专业知识和智力资源：多伦多的菲尔兹研究所、安大略癌症研究所和纳什维尔的范德比尔特综合癌症生物学中心。美国国家科学基金会资助的直接影响将是培训大量的初级美国研究人员（初级教员、博士后研究员和研究生），他们将有机会参加讲习班。这个肿瘤学跨学科项目将汇集数学/物理科学、肿瘤学家和癌症生物学家的研究人员，以解决癌症研究中的一系列具有挑战性的问题和主题。

Cancer research is at a critical juncture in the interaction of mathematical and biological knowledge for understanding cancer. Mathematical modeling of cancer dynamics has improved to such an extent that we are at a point where mathematical models can be used to probe cancer etiology and progression and guide experimental research in an informed manner. The combination of multi-scale mathematical modeling techniques and immense computing power affords the possibility of integrating basic cancer biology through genetic, sub-cellular, cellular, tissue, and epidemiologic levels. The continuation of recent research progress in this interdisciplinary field requires the training of young researchers to develop these specialized skills. This two-month program of workshops will help to produce an energetic community of young researchers in this field.The plan of this research program is the organization of multidisciplinary meetings focused on major outstanding problems in oncology. The series of meetings will combine the expertise and intellectual resources of three leading institutes: the Fields Institute in Toronto, the Ontario Institute for Cancer Research, and the Vanderbilt Integrative Cancer Biology Center in Nashville. The direct impact of NSF funding will be the training of a significant number of junior United States researchers (junior faculty, postdoctoral fellows and graduate students), who will gain the opportunity to participate in the workshops. This interdisciplinary program in oncology will bring together researchers in the mathematical/physical sciences, oncologists and cancer biologists to address a range of challenging problems and topics in cancer research.