Multifunctional Biomedical Nanosensors Based on Single Nanocomposite Nanowires

本方案的目标是开发基于单一纳米复合纳米线(NWS)(纳米材料嵌入单一导电聚合物NWS)的多功能生物医学纳米传感器。该方法是使用电化学生长的NW来构建高效的生物标记物传感器，由于所提出的NW制造的独特性质，具有工艺可控性和现场特定的方法，因此NW易于构建和重现。智能优点：在拟议的工作中，将使用单一纳米复合材料纳米WS来开发NW传感器技术。为了展示一种单一的纳米复合材料NW生物医学传感器，选择心脏传感器来检测肌红蛋白，肌红蛋白是心血管疾病(CVD)最常用的生物标志物之一。在提出的工作中，将从理论和实验两个方面研究单个NW长度与直径之间的关系，以优化传感器的性能。这项拟议的研究将提供导电聚合物与碳纳米管或纳米粒子的耦合效应的信息，以及具有机械稳定性、易于制造和导电性可控等协同效应的单个组件的性质。广泛影响：拟议的研究将发现纳米复合纳米WS在生物医学工业中的应用，这将造福我们的社会，并推动未来的技术。所提出的单一纳米复合NW技术可能导致诊断传统技术无法诊断的生物标志物的可能性。在教育工作方面，将参与现有的外展计划，如匹兹堡初级科学院(PJAS)与课程开发相关的计划。

ABSTRACTThe objective of this proposal is to develop multifunctional nanosensors for biomedical applications based on single nanocomposite nanowires (NWs) (nanomaterial-embedded single-conducting polymer NWs). The approach is to build highly efficient biomarker sensors using electrochemically grown NWs that are easily constructed and reproducible because of the unique nature of the proposed NW fabrication with process controllability and site-specific method. Intellectual Merit: NW sensor technology will be developed using single nanocomposite NWs in the proposed work. In order to demonstrate a single nanocomposite NW biomedical sensor, a cardiac sensor is selected to detect myoglobin, one of the very commonly used biomarkers for cardiovascular diseases (CVD). During the proposed work, the relationship between single NW lengths and diameters will be studied both theoretically and experimentally for optimizing sensor performances. The proposed research will provide information about the coupling effects of conducting polymers with carbon nanotubes or nanoparticles in addition to the properties of the individual components with synergistic effects such as mechanical stability, easy fabrication, and conductivity controllability.Broader Impact: The proposed research will find applications of nanocomposite NWs for biomedical industries, which will benefit our society and advance future technology. The proposed single nanocomposite NW technique could lead to the possibility of diagnosing biomarkers that cannot be diagnosed with conventional technology. For educational efforts, participation in an existing outreach program such as Pittsburgh Junior Academy of Science (PJAS) in connection with course development will be incorporated.