SGER: Design of Protein-Based Nanoscale Drug Carriers

CBET-0827852 Wang该项目研究了一种模型蛋白质系统的使用，该系统以前从未被用作纳米生物技术中的支架。而主要研究者（PI）已经在PI中建立了该表达系统？虽然该实验室已经证明了它能够容纳模型药物分子，但该项目仍然包含许多未经验证的想法。需要进行进一步的研究以建立药物释放的可行性和动力学、药物包封效率、多种类型药物分子的掺入以及调节蛋白质组装和拆卸的能力。

CBET-0827852WangThis project investigates the use of a model protein system which has never been used before as a scaffold in nanobiotechnology. While the Principal Investigator (PI) has already established this expression system in the PI?s laboratory, and has demonstrated its ability to hold model drug molecules, this project still contains a number of untested ideas. Further research needs to be performed to establish the feasibility and kinetics of drug release, drug encapsulation efficiency, incorporation of multiple types of drug molecules, and the ability to modulate protein assembly and disassembly.