SBIR Phase I: MEMS Electromagnetic Pump

这项小型企业创新研究（SBIR）第一阶段项目将开发一种基于mems的电磁泵原型，用于小型、受控或连续输送药物。与其他微泵设计相比，MEMS泵被配置为在其构建的基板平面上移动，从而使其具有相对复杂的形状，高速和大间距。这种平面结构也允许相对较大的颗粒被泵送通过微流体系统，这样基于颗粒的浆液也可以以治疗剂量输送。MEMS平面内电磁泵在电压要求、速度、泵力和可制造性等方面都优于压电泵等泵浦机构。这项研究的更广泛的影响是，这里描述的泵可以用来生产一个非常小的泵系统，适合用于皮肤上的贴片，以输送小剂量、可调节剂量的胰岛素。将泵与葡萄糖监测系统耦合可能最终形成一个人工胰腺，在可控的、连续的基础上输送胰岛素。这种对血糖水平的严格控制可以减轻大量危及生命或至少限制生命的糖尿病健康后果。该泵还可以与其他传感器耦合，以管理其他物质的控制量，或响应其他生化信号的检测，例如在治疗心血管疾病、疼痛、慢性疼痛、癌症、艾滋病、神经系统疾病、阿尔茨海默病、肝炎或帕金森病中。

This Small Business Innovation Research (SBIR) Phase I project will prototype a MEMS-based electromagnetic pump for small, controlled or continuous delivery of a drug. In contrast to other designs for micropumps, the MEMS pump is configured to move in the plane of the substrate on which it is built, allowing it to have relatively complex shape, high speed and large throw. This planar configuration also allows relatively large particles to be pumped through the microfluidic system, such that particle-based slurries can also be delivered in therapeutic doses. The MEMS in-plane electromagnetic pump has better performance than other pumping mechanisms such as piezoelectric, in terms of voltage requirements, speed, pumping force and manufacturability. The broader impacts of this research are that the pump described here may be used to produce a very small pumping system appropriate for use in an adhesive patch worn on the skin to deliver, for example, insulin in small, adjustable dosages. Coupling the pump to a glucose monitoring system may eventually form an artificial pancreas to deliver insulin on a controlled, continuous basis. Such tight control of blood glucose levels could mitigate the large number of life threatening or at least life limiting health consequences of diabetes. The pump may also be coupled to other sensors, to administer controlled volumes of other substances, or in response to the detection of other biochemical signals, for example in the treatment of cardiovascular disease, pain, chronic pain, cancer, AIDS, neurological diseases, Alzheimer's Disease, Hepatitis, or Parkinson's Disease.