CRIF: MU - Acquisition of a Cyber-Enabled Matrix Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometer

该奖项由2009年《美国复苏与再投资法案》(Public Law 111-5)颁发。借助化学研究仪器与设施多用户计划(CRIF：MU)颁发的这一奖项，来自德雷克塞尔大学的Lynn S.Penn及其同事纪海峰、Kevin G.Owens、Yanwei和Jun Zi将获得一台网络驱动的基质辅助激光解吸/电离飞行时间质谱仪(MALDI/TOF)，该仪器具有源后衰变(PSD)能力，能够精确测定大分子的分子量分布和平均分子量，并完成多肽分析。该仪器将用于了解聚合物刷子作为扩散选择性障碍的尺寸选择标准，单分散电活性聚苯胺的合成，可控尺寸树枝的合成和研究，特定蛋白质络合所涉及的特定化学位置的鉴定和表征，用于逐层形成超薄膜的聚电解质的合成，以及用于在碳纳米管上创建可控两相微结构的设计共聚物的合成。MALDI-TOF-MS是获得超大分子精确分子量的首选技术，具有极高的灵敏度。因此，使用MALDI-TOF质谱计已成为一种标准技术，特别是在涉及生物分子和聚合物的研究中。这项研究将在多个领域产生重大影响，特别是化学、材料和生物化学。该仪器将成为教学和研究不可或缺的一部分。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Chemistry Research Instrumentation and Facilities: Multiuser program (CRIF:MU), Lynn S. Penn and colleagues Haifeng Ji, Kevin G. Owens, Yen Wei, and Jun Zi from Drexel University will acquire a acquire a cyber-enabled matrix assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI/TOF) with post source decay (PSD) capabilities to provide accurate determinations of molecular weight distribution and average molecular weights of large, nonvolatile molecules, and to accomplish peptide analyses. The instrument will be used for understanding size selection criteria by which polymer brushes act as selective barriers to diffusion, synthesis of monodisperse electroactive polyanilines, synthesis and study of dendrons of controlled size, identification and characterization of the specific chemical sites involved in complexation of selected proteins, synthesis of polyelectrolytes for use in layer-bylayer formation of ultra-thin films, and synthesis of designed copolymers for creation of controlled two-phase microstructures on carbon nanotubes.MALDI-TOF-mass spectrometry is the technique of choice for obtaining accurate molecular weights on very large molecules, with extremely high sensitivity. Use of a MALDI-TOF mass spectrometer has therefore become a standard technique, especially in studies involving biomolecules and polymers. This research will have a significant impact in a number of areas, especially chemistry, materials and biochemistry. This instrument will be an integral part of teaching as well as research.