Mechanics and dynamics of biological adhesion (A08)

细胞粘附是特定的短程引力、中程排斥相互作用和远距离弹性相互作用相互竞争的结果。该项目的目标是解决这些不同的长度尺度，并研究在接触区形成的粘附键簇的形成、强度和动力学。特别是，通过采用模型系统的层次结构，我们将研究单个粘附键的动态强度、排斥分子的存在、弹性特性以及包膜（细胞皮层）的内力和外力如何影响具有最大寿命或强度的最佳簇大小。

Cellular adhesion is the result of a competition between specific short-range attractive forces, medium- range repulsive interactions and long-range elastic interactions. The goal of this project is to address these different length scales and to investigate the formation, strength and dynamics of clusters of adhesion bonds that form in the contact zone. Particularly, by employing a hierarchy of model systems, we will investigate how the dynamic strength of individual adhesion bonds, the presence of repeller molecules and the elastic properties as well as internal and external forces of the envelope (cell cortex) influence this optimal cluster size with the maximum lifetime or strength.