Variation in bacterial genomic mutation rates

我们对全球突变率的测量将有助于了解细菌的进化特性，细菌是生物圈中最多样化和最成功的有机体。细菌的变异和培养的丰富性不仅有助于生态过程，也有助于新出现的疾病。这些研究将增强在解释流行病的演变和自然界中细菌清扫的动力学方面至关重要的能力。变异还为抗生素等细菌产品的开发提供了素材。通过基因组分析了解一整套突变变化的结果将提供对进化细菌变异的最直接估计。

Our measurement of global mutation rates will contribute to an understanding of the evolutionary properties of bacteria, the most diverse and successful organisms in the biosphere. Bacterial variation and culture richness contributes not only to ecological processes but also to emerging diseases. The studies will enhance capabilities essential in interpreting the evolution of epidemics and the kinetics of bacterial sweeps in nature. Variation also provides the source material for exploitation of bacterial products such as antibiotics. The results from understanding a complete set of mutational changes through genomic analysis will provide the most direct estimates of variation in evolving bacteria.