RUI: Oxidation of Purine Derivatives Coordinated to Pt(IV) and Ru(III) Complexes

无机、生物无机和有机金属化学项目支持米德尔伯里学院Sunhee Choi教授的研究，研究鸟嘌呤和含鸟嘌呤核苷酸在铂（IV）和钌（III）络合作用下的氧化。铂和钌与核碱基的结合以及铂（IV）和钌（III）的还原与药物化学具有潜在的相关性，因为它们构成了许多类抗癌药物的基础。这项研究的科学意义影响了我们对生物和无机反应机制的理解，特别是与细胞突变、致癌、衰老和死亡有关的反应机制。本科学生将学习复杂的现代研究方法，包括实验设计和数据解释。

The Inorganic, Bioinorganic and Organometallic Chemistry Program supports the research of Professor Sunhee Choi of Middlebury College to examine oxidation of guanine and guanine-containing nucleotides facilitated by platinum(IV) and ruthenium(III) complexation. The platinum and ruthenium binding to nucleobases and the reduction of Pt(IV) and Ru(III) have potential relevance to medicinal chemistry because they form the bases of a number of classes of anticancer drugs. The scientific implications of this research impact our understanding of biological and inorganic reaction mechanisms, especially as related to cell mutagenesis, carcinogenesis, aging and death. Undergraduate students are trained in the intricacies of modern research methods including experimental design and the interpretation of data.