New Methods for the Synthesis of Peroxides

该奖项是根据2009年《美国复苏和再投资法案》(公法111-5)提供资金的。该项目将致力于开发合成有机过氧化物的新方法。过氧化氢以氧-氧键的存在为特征，存在于许多具有生物活性的天然产物中。初步数据表明，几个天然产物家族的核心结构可以通过新的化学反应来构建。这些过程将被开发，并将继续将其应用于更复杂的结构。将进行机制研究，以深入了解这些转变是如何进行的。有了这个奖项，有机和高分子化学计划将支持加州大学欧文分校化学系的基思·A·沃佩尔教授的研究。沃佩尔教授的研究重点是开发合成复杂有机分子的新化学反应。过氧物作为候选药物显示出相当大的前景，但由于其固有的不稳定性，它们很难合成。过氧化氢合成方法的成功开发将导致治疗疟疾和癌症的新药的开发。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This project will focus on the development of new methods for the synthesis of organic peroxides. The peroxide moiety, characterized by the presence of an oxygen-oxygen bond, is found in many biologically active natural products. Preliminary data suggests that the core structures of several families of natural products can be constructed by new chemical reactions. These processes will be developed, and their application to more complicated structures will be pursued. Mechanistic studies will be conducted to provide insight into how these transformations proceed.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Keith A. Woerpel of the Department of Chemistry at the University of California, Irvine. Professor Woerpel's research focuses on the development of new chemical reactions for the synthesis of complex organic molecules. Peroxides show considerable promise as drug candidates, but they are difficult to synthesize because of their inherent instability. Successful development of methods for the synthesis of peroxides would lead to the development of new drugs for the treatment of malaria and cancer.