Synthesis of Heterocycles via New Metal-Catalyzed Transformations

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。本计画的目标是发展实用的催化剂，以过渡金属催化活化炔类化合物选择性合成杂环分子。重点介绍了五元唑类杂环化合物的合成。这些研究将涉及催化剂的设计，其活性的调查，以及反应机理的检查，代表了反应发现和实际工艺开发的各个方面。热流量热法、平行合成和反应监测以及实验算法设计将用于研究和优化新反应性的初步发现。有了这个奖项，有机和大分子化学计划将支持斯克里普斯研究所化学系的Valery V. Fokin教授的研究。 Fokin教授的研究项目围绕着开发实用的催化方法，通过C-N键的形成从容易获得的炔合成杂环分子。 该方法的成功开发将对制药，材料和农业工业的合成产生影响。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). The goal of this project is to develop practical catalysts for the selective synthesis of heterocyclic molecules by transition metal-catalyzed activation of alkynes. The emphasis is placed on the synthesis of the five-membered azole heterocycles. The studies will involve design of the catalysts, investigation of their activity, and examination of the mechanism of the reactions, representing all aspects of reaction discovery and practical process development. Heat flow calorimetry, parallel synthesis and reaction monitoring, and design of experiments algorithms will be used to study and optimize the initial discoveries of novel reactivity.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Valery V. Fokin of the Department of Chemistry at The Scripps Research Institute. Professor Fokin's research program revolves around the development of practical catalytic methods for the synthesis of heterocyclic molecules from readily available alkynes via formation of C-N bonds. Successful development of the methodology will have an impact on synthesis in the pharmaceutical, materials, and agricultural industries.