Annotating unknown microbial gene functions with organic matter change

本项目旨在开发一种测定微生物基因组功能的新方法。微生物在地球上无处不在。现在对微生物基因组进行常规测序已经成为可能。然而，在这些基因组上编码的大多数基因的功能仍然难以捉摸，严重限制了我们对大多数生态系统的理解。该项目旨在通过将模型永久冻土解冻泥炭地中代谢物丰度的变化与基因表达相关联，开发新的方法来分配未表征基因的功能。确定未表征基因的功能对微生物生态学及其在现实世界中的许多应用具有广泛的意义，从确定土壤温室气体排放到了解人类肠道菌群。

This project intends to develop a new method for determining the function of microbial genomes. Microbes are all pervasive on Earth. It is now possible to routinely sequence microbial genomes. However, the function of most genes encoded on these genomes remains elusive, severely limiting our understanding of most ecosystems. This project seeks to develop new methods to assign function to uncharacterised genes, by correlating changes in metabolite abundance with gene expression in a model permafrost thaw peatland. Determining the function of uncharacterised genes has widespread implications for microbial ecology and its numerous real-world applications, from determining soil greenhouse gas emissions to understanding human intestinal flora.