Interface Pressure Sensors for Plaster Cast and Other Biomedical Applications

这项提案将使用2009年《美国复苏和再投资法案》(公法111-5)提供的资金授予，并符合2009年3月20日题为《确保负责任地使用复苏法案资金》的白宫备忘录第2节规定的要求。作为认知项目官员，我还确认，该提案不支持《复苏法案》A分部第1604节所述的项目。本项目的研究目标是面向生物医学应用的亚厘米级无电池无线接口压力传感器。间隔室综合征是一种非常严重的并发症，由于肿胀而发生在管型中，可导致缺血、坏死和严重的神经损伤。随着本项目研究和开发的传感器系统，间隔综合征可以通过监测石膏内部的皮肤表面压力来预防。拟议的无线传感器还具有大量其他生物医学应用，包括用于膝关节植入物、髋关节植入物、假体设计、用于测量患有神经病变的糖尿病患者的足底压力，以及用于预防卧床或坐轮椅的患者的床疮。MEMS接口压力传感器将采用一种新的电感耦合策略，在该策略中，基于频域的算法将补偿传感器和远程询问器之间的距离和方向变化。研究任务包括无线MEMS传感器的设计和制造、频域和自适应估计算法的评估、无线遥测研究以及模拟管型(包括血压袖带)中的无线传感器的实验评估。该项目的教育阶段包括纳入重点为高地公园高中在校学生的医疗传感器系统的课堂项目。该项目还将通过一个专门的暑期REU项目招收少数族裔和女性本科生，为她们提供从事尖端研究的机会，并激励她们继续研究生学习。

This proposal will be awarded using funds made available by the American Recovery and Reinvestment Act of 2009 (Public Law 111-5), and meets the requirements established in Section 2 of the White House Memorandum entitled, Ensuring Responsible Spending of Recovery Act Funds, dated March 20, 2009. I also affirm, as the cognizant Program Officer, that the proposal does not support projects described in Section 1604 of Division A of the Recovery Act. The research objective of this project focuses on sub-centimeter sized battery-less wireless interface pressure sensors for biomedical application. Compartment Syndrome is a very serious complication that occurs in a cast due to swelling and can cause ischemia, necrosis and serious nerve injuries. With the sensor systems investigated and developed in this project, Compartment Syndrome can be prevented by monitoring the skin surface pressure inside the cast. The proposed wireless sensors also have a significant number of other biomedical applications, including their use in knee implants, hip implants, prosthesis design, their use for measurement of footprint pressures in diabetic patients with neuropathy and for prevention of bed sores in patients confined to beds or wheelchairs. MEMS interface pressure sensors will be developed with a novel inductive coupling strategy in which frequency domain based algorithms compensate for varying distance and orientation between the sensor and remote interrogator. The research tasks include design and fabrication of the wireless MEMS sensors, evaluation of frequency domain and adaptive estimation algorithms, wireless telemetry studies and experimental evaluation of the wireless sensors inside a simulated cast that includes a blood pressure cuff. The educational phase of the project include incorporation of class projects focused on medical sensor systems for school students from the Highland Park High School. The project will also recruit minority and women undergraduate students through a specialized summer REU program, providing them an opportunity to work on cutting edge research and motivating them to pursue graduate studies.