Mitochondrial proteases and their contribution to protein homeostasis

这项研究将研究一个至关重要的细胞器，称为细胞器，如何通过传感和信号蛋白质扰动保持其功能的完整性。由于线粒体功能障碍是许多神经退行性疾病的核心，因此了解这一至关重要的细胞过程的分子生物学可以在未来为澳大利亚老龄人口提供更好的健康结果。研究生的培训是这项研究的一个组成部分，因此将有助于建设国家研究能力。国际合作和新发现也将有助于澳大利亚研究的认可。

This research will examine how a critically important cellular organelle known as the mitochondrion maintains its functional integrity by sensing and signalling protein perturbations. As mitochondrial dysfunction is central to a number of neurodegenerative diseases understanding the molecular biology of this fundamentally important cellular process could, in the future, provide for better health outcomes for an aging Australian population. The training of post-graduate students is an integral component of this study and thus will contribute to building national research capacity. International collaborations and new discoveries will also contribute to the recognition of Australian research.