RUI: Selective Oxidative Transformations Using Water-Soluble Hypervalent Iodine Reagents

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。该项目将继续致力于开发和优化使用水溶性高价碘试剂的不同化学选择性氧化程序。 本项目期间寻求的一些重要目标是开发用户和生态友好的程序，以选择性地在酮中引入α，β-不饱和而不是醛，在不对称酮中引入具有可预测区域化学的α，β-不饱和，潜在的和可能的选择性氧化脂肪醛而不是芳香醛。 该项目还试图测试邻碘酰苯甲酸衍生物与高价碘中心邻位取代基的反应性的理论预测。 该项目的潜在绿色化学主题、使用水性溶剂混合物作为反应介质以及在环境友好的共氧化剂存在下在催化条件下进行合成有用的氧化转化的可行性是当前项目值得关注的方面。有了这个奖项，有机和高分子化学计划是支持教授T。K.西伊利诺伊大学化学系的Vinod说。 Vinod教授和他的学生正在开发程序，包括催化程序，用于在水性溶剂混合物中选择性氧化官能团。 对高中、理学士和理学硕士学生进行化学研究艺术和潜在的绿色化学主题（通过设计更安全的化学程序）的培训是该项目更广泛和长期的优点。 本提案中概述的化学选择性氧化方法的成功开发将对制药和农业工业的合成产生影响。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This project will continue work on the development and optimization of different chemoselective oxidation procedures using water-soluble hypervalent iodine reagents. Development of user and eco-friendly procedures for the selective introduction of alpha, beta-unsaturation in ketones over aldehydes, introduction of alpha, beta-unsaturation with predictable regiochemistry in unsymmetrical ketones, potential and possible selective oxidation of aliphatic aldehydes over aromatic aldehydes are some of the important goals sought during the present project period. The project also seeks to test the theoretical predictions on the reactivity of o-Iodoxybenzoic Acid derivatives with substituents ortho to the hypervalent iodine center. Underlying green chemistry themes of the project, the use of aqueous solvent mixtures as reaction media and the feasibility of carrying out the synthetically useful oxidative transformations under catalytic conditions in the presence of environmentally friendly co-oxidants are worthwhile aspects of the current project. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor T. K. Vinod of the Department of Chemistry at Western Illinois University. Professor Vinod and his students are developing procedures, including catalytic procedures, for the selective oxidation of functional groups in aqueous solvent mixtures. The training of high school, BS and MS students in the art of chemical research and the underlying green chemistry theme (by devising safer chemical procedures) are broader and long-term merits of this project. Successful development of the chemoselective oxidation methodologies outlined in the current proposal will have an impact on synthesis in the pharmaceutical and agricultural industries.