MRI: Acquisition of a 400-MHz NMR Spectrometer to Support Faculty-Student Research and Training at WIU and Partner Institutions

与此奖项从主要研究仪器计划是由化学研究仪器和设施（CRIF）计划共同资助，教授T.K.来自西伊利诺伊大学的Vinod及其同事Brian Bellott，Jin Jin，Shaochong Zhang和Rose McConnell将获得400 MHz NMR光谱仪。该项目旨在加强各级的研究和教育，特别是在以下领域：（a）水溶性高价碘试剂的合成和反应;（B）使用原位生成的芳基碘鎓离子，以过硫酸氢钾为终端氧化剂，氧化裂解烯烃;（c）设计和开发用于课堂活动的绿色氧化实验;（d）组织蛋白酶抑制剂的合成和表征;（e）13 C标记的亮抑酶肽类似物的基于NMR的平衡研究;（f）有机硒抗氧化剂的合成;（g）使用硒或碲荧光探针定量检测重金属;（h）含碲和硅的大环化合物的合成和研究;（i）膦在催化体系中的空间和电子贡献;和（j）亲富勒烯体的合成。核磁共振（NMR）光谱是化学家可用于阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为教学和研究的一个组成部分，不仅在西伊利诺伊大学，而且在合作机构，如昆西大学和卡尔桑德堡学院。

With this award from the Major Research Instrumentation Program that is co-funded by the Chemistry Research Instrumentation and Facilities (CRIF) Program, Professor T.K. Vinod from Western Illinois University and colleagues Brian Bellott, Jin Jin, Shaozhong Zhang and Rose McConnell will acquire a 400 MHz NMR spectrometer. The project is aimed at enhancing research and education at all levels, especially in areas such as (a) synthesis and reactions of water-soluble hypervalent iodine reagents; (b) oxidative cleavage of alkenes using an in-situ generated aryliodonium ion with oxone as terminal oxidant; (c) design and development of green oxidation experiments for the classroom activities; (d) synthesis and characterization of cathespsin inhibitors; (e) NMR based equilibrium studies of 13C labeled leupeptin analogues; (f) synthesis of organoselenium antioxidants; (g) quantitative detection of heavy metals using a seleno or telluro fluorescent probe; (h) synthesis and study of tellurium and silicon containing macrocycles; (i) steric and electronic contributions of phosphines in catalytic systems; and (j) synthesis of fulleridophiles.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research not only at Western Illinois University but also at collaborating institutions such as Quincy University and Carl Sandburg College.