Catalytic Regioselective Functionalization of Alkane and Arenes

这个无机、生物无机和有机金属化学项目的研究奖支持伊利诺伊大学厄巴纳-香槟分校的John F. Hartwig教授在典型不反应的C-H键上的反应。这项工作将创造新的方法，通过在大多数试剂惰性的位置选择性化学转化来制备有机分子。在过渡金属和硼之间含有键的配合物催化了这些反应，这项资助将揭示导致这种不寻常反应的过渡金属的性质。这些配合物催化的反应已经并将继续应用于合成具有新性质的聚合物、具有增强发光能力的有机分子、其他反应的催化剂组分以及用于理解生物系统的有机探针。拟议的研究工作是课堂新课程、短期课程、许多外部讲座和一个主要教科书项目的一部分，该项目将在PI的下一个拨款期内完成。这项研究将带来新的方法，以更少的步骤、更少的浪费、更少的依赖于官能团的安装和保护来进行化学合成。此外，这项研究还为未来设计更有效的合成催化剂和工艺奠定了基础。研究如何定义金属的电子性质以及反应配体的亲电或亲核性质如何影响C-H键的切割和功能化将创造这些原则。

This research award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor John F. Hartwig at the University of Illinois at Urbana-Champaign to develop reactions at typically unreactive C-H bonds. This work will create new methods to prepare organic molecules by selective chemical transformations at positions that are inert to most reagents. Complexes containing bonds between transition metals and boron catalyze these reactions, and this grant will reveal the properties of the transition metal that lead to this unusual reactivity. The reactions catalyzed by these complexes have been and will continue to be applied to the synthesis of polymers containing new properties, organic molecules with enhanced abilities to emit light, components of catalysts for other reactions, and organic probes for understanding biological systems. Work emanating from the proposed research is part of new curricula for the classroom, short-courses, many external lectures, and a major textbook project that will be completed in the next grant period by the PI.This research will lead to new methods to conduct chemical synthesis in fewer steps, with less waste, and with less reliance on the installation and protection of functional groups. In addition, this research creates the underlying principles on which future design of catalysts and processes for more efficient synthesis are based. Studies to define how the electronic properties of the metal and how electrophilic or nucleophilic properties of the reactive ligand affect C-H bond cleavage and functionalization will create these principles.