POWERFUL NEW RUTHENIUM-CATALYZED TANDEM PROCESSES

鉴于钌络合物可以催化的反应范围广泛，该提议集中于开发由已知和新的钌络合物实现的“一锅法”多步法。 所提出的研究的总体结果将是更有效的串联方案，用于将含有简单烯烃的起始材料转化为更复杂和有价值的目标。 具体地，强有力的烯烃复分解反应将与其他复杂性构建转化（例如环丙烷化、金属介导的偶联、氧化、环加成、异构化和自由基原子转移反应）偶联，以产生高度独特和有价值的、铼催化的串联转化。 有了这个奖项，NSF的有机和高分子化学计划支持波士顿学院化学系Snapper教授的研究。 Marc Snapper教授的研究涉及开发更高效和更有效的债券形成策略。在单个操作中实现多个复杂官能团和键变化的能力可以代表获得有用有机化合物的效率的显著提高。 此外，通过消除中间体的分离而使时间、劳动力、溶剂、试剂、能量、废物流和材料损失最小化将显著降低制备所需靶的成本和环境影响。总的来说，这项研究将导致新的，更强大的反应和分子构建策略，这将降低制备当前和未来重要分子的成本和环境影响。

Given the wide range of reactions that ruthenium complexes can catalyze, this proposal focuses on the development of "one-pot" multi-step processes effected by known and new ruthenium complexes. The overall outcome of the proposed research will be more efficient tandem protocols for converting simple olefin containing starting materials into much more complex and valuable targets. Specifically, the powerful olefin metathesis reaction will be coupled with other complexity-building transformations, such as cyclopropanations, metal mediated couplings, oxidations, cycloadditions, isomerizations and radical atom transfer reactions to yield highly unique and valuable, ruthenium-catalyzed, tandem transformations. With this award, the Organic and Macromolecular Chemistry Program at the NSF is supporting the research of Professor Snapper of the Department of Chemistry at Boston College. Professor Marc Snapper's research involves the development of more efficient and effective bond-forming strategies. The ability to effect multiple complex functional group and bond changes in a single operation can represent a considerable improvement in efficiency for accessing useful organic compounds. Moreover, minimizing the time, labor, solvents, reagents, energy, waste streams, and material losses by eliminating the isolation of intermediates will significantly reduce the cost and environmental impact of preparing desired targets. In general, this research will lead to new, more powerful reactions and molecule building strategies that will lower the cost and environmental impact of preparing current and future molecules of importance.