MRI: Acquisition of Instrumentation for Proteomics Research or Training Encompassing Investigators' Needs Lab at SJSU (PROTEIN Lab)

国家科学基金会授予圣何塞州立大学(SJSU)开发蛋白质组学设施的资金。该项目的目标是改造和扩大上海州立大学的分子生命科学研究能力。这是化学系和生物系教员之间的合作努力，除了目前存在的一对一联系外，还旨在促进这两个系之间的机构联系。这一目标将通过在上海交通大学建立蛋白质实验室，发展分子生命科学研究方面的教员专业知识，以及培训上海交通大学的学生进行蛋白质组学研究来实现。该计划将推动各种科学进步，包括鉴定生物信号转导途径中的新蛋白质，表征来自不同生物来源的新蛋白质，如从不可培养的细菌到人类，纯化蛋白质，用于蛋白质拥挤和水合效应的生物物理研究，以及小分子的表征。该计划将增强生物和化学系的研究能力，促进使用蛋白质设施的研究人员之间的合作，并为研究生和本科生过渡到研究生/专业课程或旧金山湾区的生物技术工作队伍做好准备。研究项目的成果将发表在同行评议的期刊上，并通过学生和教职员工在地区或国家会议上的演讲进行传播。

The National Science Foundation has awarded San José State University (SJSU) funds to develop a proteomics facility. The goal of this project is to transform and expand the molecular life sciences research capabilities at SJSU. This is a collaborative effort between faculty in the Departments of Chemistry and Biology to foster institutional linkages between the two departments in addition to the one-on-one linkages that currently exist. This goal will be accomplished through the establishment of the PROTEIN Lab at SJSU, developing faculty expertise in molecular life science research, and training SJSU students in proteomics research. This program will enable a variety of scientific advances, including identification of novel proteins in biological signal transduction pathways, characterization of novel proteins from diverse biological sources such as uncultivable bacteria to humans, purification of proteins for biophysical studies of protein crowding and hydration effects, and characterization of small molecules. This program will enhance the research capabilities in the Departments of Biology and Chemistry, stimulate collaboration amongst researchers who use the PROTEIN facility, and prepare graduate and undergraduate students for transition to graduate/professional programs or the biotechnology work force in the Bay Area. Results from the research projects will be published in peer-reviewed journals, and disseminated through presentations by students and faculty at regional or national meetings.