Classical and instrumental conditioning of brain-communication and neuronal connectivity

在这里，语义和情感的大脑沟通与完全瘫痪，非常小的儿童和晚期痴呆症患者的未解决的问题，将通过使用两个过程（经典-操作）学习诱发和振荡的大脑活动和实时模式分类的情绪大脑反应与代谢（BOLD）和神经电（EEG）信号的记录。其次，由于目标导向的感觉运动行为是由大型神经元组件中的动态连接模式引起的，因此使用实时功能性磁共振成像（rt-fMRI）、近红外光谱（NIRS）和脑磁图（MEG）/EEG交叉相干来进行这种大脑连接模式的仪器（奖励）学习是使用精神病行为和恋童行为障碍来进行的，以及在瘦的和肥胖的人中进食，作为特别高的抗改变的大脑行为模式的模型系统。为了改善学习和神经可塑性，将在某些实验条件下使用非侵入性经颅直流电刺激（tDCS）。虽然脑机接口（BCI）研究在认知神经科学中的传统很短，但所提出的项目和方法不能依赖于以前的科学传统：只有Koselleck资助申请计划适合这种情况。除了为这些治疗抵抗性疾病提供新的和可能更有效的非侵入性行为治疗解决方案的临床目的外，所提出的实验还提供了对一些基本理论问题的见解：（a）意志的“恢复”（工具性行为）在长期麻痹和目标导向行为和思想消退后B）意志力在生命之初和人类认知生命末期的发展。c）编码和修改重复性破坏性和自我破坏性行为的最佳学习图式及其大脑激活模式，如精神病患者的工具性攻击和暴饮暴食。d）哪些相互关联的大脑活动模式对于重建这些抵制变化的行为是必不可少的？

Here, the unresolved problem of semantic and emotional brain communication with the completely paralyzed, very small children and patients with advanced dementia will be investigated by using twoprocess (classical – operant) learning of evoked and oscillatory brain activity and real-time pattern classification of emotional brain responses with recording of metabolic (BOLD) and neuroelectric (EEG) signals. Second, since goal directed sensorimotor behavior results from dynamic connectivity patterns in large neuronal assemblies instrumental (reward) learning of such brain connectivity patterns with real-time functional magnetic resonance imaging (rt-fMRI), near infrared spectroscopy (NIRS) and magnetoencephalography (MEG)/EEG-cross-coherence is performed using psychopathic behavior and pedophilic behavior disorder, and eating in lean and obese persons as model systems of particularly high change-resistant brain-behavior patterns. To improve learning and neural plasticity non-invasive transcranial DC-stimulation (tDCS) will be used in some of the experimental conditions. While braincomputer- interface (BCI) research has a short tradition in the cognitive neurosciences the proposed project and methodology cannot rely on previous scientific tradition: only the Koselleck grant application scheme is appropriate for this situation. In addition to the clinical purpose in providing new and probably more efficient non-invasive behavioral therapeutic solutions for these treatment-resistant disorders the proposed experiments provide insight into some fundamental theoretical problems: a) The “restoration” of volition (instrumental behaviour) after prolonged paralysis and extinction of goal directed behavior and thought b) The development of volition at the beginning of life and during the terminal phases of cognitive human life. c) The optimal learning schemas for encoding and modification of repetitive destructive and autodestructive behaviors and their brain activation patterns such as instrumental aggression in psychopathy and overeating. d) Which patterns of interconnected brain activity are indispensable for the reconstruction of these change-resistant behaviors?