Apoptotic signalling in virally infected and normal cells.

在澳大利亚和国际上，病毒性疾病是造成死亡率和发病率的主要原因。包括H5N1禽流感在内的新出现的病毒性疾病有可能严重影响人类健康和全球经济。人们还担心病毒可能被用作生物武器。该项目旨在确定健康细胞中细胞死亡发生和调节的机制，以及病毒感染或致癌转化细胞如何改变这一机制。这项工作的结果可能有助于开发新的抗癌和抗病毒疗法、诊断试剂和疫苗。

Viral diseases contribute substantially to mortality and morbidity, in Australia and internationally. Emerging viral diseases, including H5N1 avian influenza, have the potential to severely impact on human health and the global economy. Concerns also exist that viruses may be used as bioweapons. This project seeks to define the mechanisms by which cell death occurs and is regulated in healthy cells, and how this is altered in virally infected or oncogenically transformed cells. Outcomes of this work may contribute to development of novel anti-cancer and anti-viral therapies, diagnostic reagents and vaccines.