Development of Modular NHC Ligands for Catalysis

该项目侧重于开发一种配体类型的构建块，该配体类型已被证明可以提供具有独特反应活性的金属配合物，n -杂环碳（NHC）配体。NHCs正被用作各种过渡金属催化剂的配体，在许多情况下具有比先前研究的配体更好的反应性。它们已被证明在许多重要的反应中起作用，其中最重要的可能是烯烃复分解。此外，NHCs在亲核催化领域具有活性。这项工作将开发方法来提供促进各种不同NHC配体合成的构建块。本工作中发展的方法将有助于合成各种n -杂环碳烯和更多数量的过渡金属配合物。有了这个奖项，化学合成项目支持了休斯顿大学化学系斯科特·r·吉尔伯森教授的研究。吉尔伯特森教授的研究工作围绕着开发新的催化配体。新催化剂的发现常常受到新配体可用性的限制。因此，化学的发展提供了获得新配体类型的途径是重要的。新型和高效的催化剂对许多产品的生产至关重要，包括治疗剂、农用化学品和商品化学品。

This project focuses on a plan to develop building blocks for a ligand type that has been shown to provide metal complexes possessing unique reactivity, N-heterocyclic carbene (NHC) ligands. NHCs are being exploited as ligands for a variety of transition metal catalysts, in a number of cases possessing better reactivity than ligands investigated previously. They have been shown to be instrumental in a number of important reactions the most important of which may be olefin metathesis. Additionally, NHCs have demonstrated activity in the area of nucleophilic catalysis. This work will develop approaches to provide building blocks that facilitate the synthesis of a variety of different NHC ligands. The methods developed in this work will facilitate the synthesis of a wide variety of N-heterocyclic carbenes and an even larger number of transition metal complexes. With this award, the Chemical Synthesis program is supporting the research of Professor Scott R. Gilbertson in the Department of Chemistry at the University of Houston. Professor Gilbertson's research efforts revolve around the development of new ligands for catalysis. The discovery of new catalysts is often limited by the availability of new ligands. Consequently, the development of chemistry that provides access to new ligand types is important. New and efficient catalysts are critical in the manufacturing of many products, including therapeutic agents, agrochemicals, and commodity chemicals.