Environmentally Friendly Organophosphorus Chemistry

该项目将继续开发磷-碳键形成反应。 提出了基于次磷酸及其衍生物和H-次膦酸盐的新的催化反应，以提供原子经济的过程。 具体而言，这些努力涉及a）在过渡金属催化下烷基次膦酸酯中的P-H活化，包括在主要研究者的实验室中发现的钯和镍催化的氢化膦化的进一步发展; B）H-次膦酸酯中的P-H活化;和c）在有机磷化合物的制造中逐步淘汰磷的氧化物，从而通过催化制备和使用H-次膦酸盐减少与氯使用相关的环境影响和能量需求。H-Phosphinate衍生物具有磷的中间氧化态，它们可以衍生成大量其他重要的官能团。凭借该奖项，化学合成项目支持德克萨斯基督教大学化学系Jean-Luc Montchamp教授的研究。 Montchamp教授的研究工作围绕着在催化条件下形成P-C和P-O键的方法的发展。 这种化学将有助于有机磷化合物的化学合成的环境友好的方法，这是重要的许多产品，如治疗剂，农用化学品和膦配体的催化制造。

This project will continue the development of phosphorus-carbon bond-forming reactions. New catalytic reactions are proposed based on hypophosphorous acid and its derivatives, and on H-phosphinates to provide atom-economical processes. Specifically, these efforts involve a) P-H activation in alkyl phosphinates under transition-metal catalysis, including further developments of the palladium- and nickel-catalyzed hydrophosphinylations discovered in the principal investigator's laboratory; b) P-H activation in H-phosphinates; and c) phasing out phosphorus trichloride in the manufacturing of organophosphorus compounds, thereby reducing the environmental impact and energy-demand associated with chlorine usage through the catalytic preparation and use of H-phosphinates. H-Phosphinate derivatives possess an oxidation state in the middle of the range for phosphorus, and they can be derivatized into a plethora of other important functional groups.With this award, the Chemical Synthesis program is supporting the research of Professor Jean-Luc Montchamp of the Department of Chemistry at Texas Christian University. Professor Montchamp's research efforts revolve around the development of methodology for the formation of P-C and P-O bonds under catalytic conditions. Such chemistry will contribute to environmentally benign methods for the chemical synthesis of organophosphorus compounds, which are important in the manufacturing of many products, such as therapeutic agents, agrochemicals, and phosphine ligands for catalysis.