CAREER: Enabling the Synthesis of Nitrogen-Containing Complex Molecules

有了这个CAREER奖，化学合成项目支持了加州大学洛杉矶分校的Neil K. Garg教授的研究。Garg教授将开发合成含氮复合分子的新方法。首先，将开发合成吲哚或吲哚的任何衍生物的方法。这些努力将使对基本吲哚反应性的各种研究成为可能。其次，Garg教授将揭示制备融合吲哚的方法，这是在自然发生的复杂分子中经常遇到的基序。后一种方法将应用于aspidophyline A的全合成，aspidophyline A是一种有趣的生物碱，具有密集功能化的糠吲哚碱核心。Garg教授还将承担三个研究与教学相结合的教育项目。第一个项目涉及针对当地一所高中的外展计划，该高中主要服务于代表性不足的群体。第二个教育项目涉及与NSF本科生研究经验（REU）计划的互动，其中Garg教授将担任国际NSF/REU计划的校友顾问。最后，将建立一个广泛的合成有机化学网站，利用视觉辅助来传达化学合成的重要性，并解释各种实验技术。

With this CAREER award, the Chemical Synthesis program is supporting the research of Professor Neil K. Garg of the University of California, Los Angeles. Professor Garg will develop new methodologies for the synthesis of nitrogen-containing complex molecules. First, methods for synthesizing indolynes, or aryne derivatives of indoles, will be developed. These efforts will enable various studies of fundamental indolyne reactivity. Second, Professor Garg will uncover methods for preparing fused indolines, motifs often encountered in naturally occurring complex molecules. This latter methodology will be applied toward the total synthesis of aspidophylline A, an intriguing alkaloid that possesses a densely functionalized furoindoline core.Professor Garg will also undertake three educational projects that interweave research and teaching. The first project involves an outreach program targeting a local high school that predominantly serves underrepresented groups. The second educational project involves interactions with the NSF Research Experience for Undergraduates (REU) program, where Professor Garg will serve as an alumni advisor for the international NSF/REU program. Finally, an extensive synthetic organic chemistry website will be created that utilizes visual aids to convey the importance of chemical synthesis and explain various experimental techniques.