Total Synthesis of Complex Molecules

复杂分子的全合成

• 批准号: 1464898
• 负责人: Neil Garg
• 金额: $ 42万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1464898&HistoricalAwards=false
• 关键词: Total; Synthesis; Complex; Molecules

With this award, the Chemical Synthesis program is supporting fundamental research of Professor Garg at the University of California, Los Angeles. Professor Garg will pursue the chemical synthesis of several naturally occurring small molecules that possess challenging chemical structures and promising biological activities. The ability of scientists to build molecules with increased complexities, in a controlled and efficient manner, plays an important role across all of the fields that are impacted by chemical synthesis, such as drug discovery, agrochemistry, and materials science. Professor Garg will also continue his ongoing efforts to promote science to young people and the general public. This will be performed primarily through outreach activities and through initiatives that are intended to challenge existing paradigms in undergraduate education. The research involves an important class of indole alkaloids called the akuammilines. Over 30 molecules in this family have been isolated during the past century, all of which possess intricate chemical structures. However, relatively little progress has been made in the area of akuammiline alkaloid synthesis to date, especially in comparison to structural relatives such as the well-studied strychnos alkaloids. Professor Garg aims to establish a unified synthetic approach that will provide access to various structural subclasses of the akuammilines in an asymmetric fashion. In addition to delivering several akuammilines that have not been accessed previously, the proposed efforts will allow Garg's laboratory to probe the intricacies and complexities of late-stage transformations and establish the scope and limitations of synthetic methodologies, such as interrupted Fischer indolization reactions.

有了这个奖项，化学合成项目支持加州大学洛杉矶分校Garg教授的基础研究。Garg教授将从事几种天然小分子的化学合成，这些小分子具有具有挑战性的化学结构和有前途的生物活性。科学家以可控和有效的方式构建复杂性增加的分子的能力，在受化学合成影响的所有领域（如药物发现、农业化学和材料科学）中发挥着重要作用。Garg教授亦会继续致力向年青人及公众推广科学。这将主要通过外展活动和旨在挑战现有本科教育模式的举措来实现。这项研究涉及到一种重要的吲哚类生物碱，称为阿库胺类。在过去的一个世纪里，这个家族中有30多个分子被分离出来，它们都具有复杂的化学结构。然而，迄今为止，在阿库马胺类生物碱的合成领域取得的进展相对较少，特别是与结构上的近亲，如经过充分研究的马钱子生物碱相比。Garg教授的目标是建立一种统一的合成方法，以不对称的方式提供对akuammilines的各种结构子类的访问。除了提供一些以前没有接触过的akuammilines之外，拟议的努力将使Garg的实验室能够探索后期转化的复杂性和复杂性，并确定合成方法的范围和局限性，例如中断Fischer吲哚化反应。