Robust, Efficient and Orthogonal Synthesis of Polymeric Materials

在这个由化学部高分子、超分子和纳米化学计划资助的项目中，加州大学圣巴巴拉分校的克雷格·霍克将开发利用烯酮化学作为合成工具来创建模块化聚合物和软材料的策略。该方法是从梅尔德鲁姆酸及其衍生物中发现低温、定量生成酮的反应条件。然后将前驱体部分放置在聚合物的侧链、链端和内部以及表面上，以探索这种底物的模块化化学官能化，利用烯类化合物丰富的化学成分。更广泛的影响包括通过开发一门关于交流和演示设计的课程来促进教学、培训和学习，组织一次关于聚合物和材料合成的点击化学方法的ACS研讨会，以及资助当地少数族裔本科生参加陶氏基金会讲座系列。这项工作将扩大可用于创造新聚合物和材料的化学技能。这些研究的结果可能会对聚合物材料重要的各种应用和行业产生许多重要的长期影响，包括精细化工、涂料、电子和生物技术。

In this project funded by the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division, Craig Hawker of the University of California at Santa Barbara will develop strategies for utilizing ketene chemistry as a synthetic tool for creating modular polymer and soft materials. The approach is to discover reaction conditions for the low temperature, quantitative generation of ketenes from Meldrum's acid and its derivatives. The precursor moieties would then be placed at the side chains, chain ends and interiors of polymers and on surfaces in order to explore the modular chemical functionalization of such substrates, exploiting the rich chemistry of ketenes. The broader impacts involve advancing teaching, training and learning through the development of a course on communication and presentation design, organizing an ACS Symposium on "click" chemistry approaches to polymer and materials synthesis, and funding local minority undergraduate students to attend the Dow Foundation Lecture Series.This work will expand the repertoire of chemistry that can be used to create new polymers and materials. The results of these studies could have many important long term impacts on a variety of applications and industries in which polymeric materials are important, including fine chemicals, coatings, electronics, and biotechnology.