MRI-R2: Acquisition of High Throughput Crystallization and Collection Devices

该奖项由2009年《美国复苏与再投资法案》(Public Law 111-5)资助。这一重大研究仪器回收与再投资(MRI-R2)奖项资助华盛顿州立大学(WSU)生物分子X射线结晶学(BXC)中心购买高通量结晶和收集设备。从收购中受益的研究包括调查DNA损伤和修复机制、生殖生理学、防御生物恐怖主义、全球主要疾病的原因和预防、植物防御系统、氧化还原化学、蛋白质折叠、食品和可再生能源生产以及减少环境污染等项目。结晶的自动化和双波长(铜和铬阳极)高通量X射线发生器的可用性大大提高了整体的科学性，并使北京X射线中心成为高通量结构确定的区域中心。高通量设备的提供使BXC中心不仅可以持续解决每一项正在进行的合作中最引人注目的科学问题，而且还可以扩大合作和服务范围，将新的邻近研究所包括在内。该仪器为区域研究和教学界提供了扩展和高效的服务，通过访问和利用核心来共同加强他们的科学计划。BXC中心与全国各地的许多机构进行了大量的服务和外部合作，并通过实验室实验和课堂教学，积极增强研究生、本科和高中水平的区域教学和培训能力。高通量设备增加了该中心在该地区的作用，培养出来自不同经济、种族和地理背景的下一代世界级科学家。由新设备实现的研究结果通过学生和教职员工在地区和国家会议上的陈述以及通过在同行评议的期刊上发表来传播。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).This Major Research Instrumentation-Recovery and Reinvestment (MRI-R2) award funds the acquisition of high throughput crystallization and collection devices at the Biomolecular X-ray Crystallography (BXC) Center at Washington State University (WSU). Research benefitting from the acquisition includes projects to investigate mechanisms of DNA damage and repair, reproductive physiology, defense against bioterrorism, causes and prevention of major worldwide diseases, plant defense systems, redox chemistry, protein folding, production of food and renewable energy, and reduction of environmental pollution. Automation of crystallization and availability of high flux X-ray generators with dual wavelengths (Cu and Cr anodes) has significantly enhanced the overall scientific, and establishes the BXC Center as a regional center for high-throughput structure determination. The availability of the high throughput devices allows the BXC Center to not only continuously address the most compelling scientific questions in each of those on-going collaborations but also allows expansion of the collaborations and services to include new neighboring institutes. The instrumentation provides extended and efficient service for the regional research and teaching community to collectively enhance their scientific programs via access to and utilization of a core. The BXC Center performs numerous services and external collaborations with many institutions across the Nation, and is active in enhancing regional teaching and training capabilities at the graduate, undergraduate, and high school level through laboratory experiments and classroom instruction. The high throughput devices increases the Center's role in this region to produce world-class scientists of the next generation derived from diverse economic, ethnic and geographic backgrounds. Results from the studies enabled by the new equipment are disseminated by student and faculty presentations at regional and national meetings, and through publication in peer-reviewed journals.