Research Starter Grant: The population genetics of adaptation

该项目将发展统计理论和方法，利用全基因组多态性数据来表征DNA序列的适应性进化。这些方法将显著改善最近选择性事件的识别和定位，并提供长期寻求的关于有益固定的强度和速率的基因组分布的信息。鉴于基因组数据的可用性迅速增加，这项工作尤其及时。了解适应的产物和过程对于连接遗传和表型信息至关重要。该项目将通过继续促进计算和经验小组以及功能和进化实验室之间的伙伴关系来增强研究基础设施。

This project will develop statistical theory and methodology to characterize adaptive evolution in DNA sequences using whole genome polymorphism data. These approaches will significantly improve the identification and localization of recent selective events, and provide long sought information regarding the genomic distributions of the strengths and rates of beneficial fixations. This work is especially timely given the rapid increase in the availability of genomic data. Understanding of the products and processes of adaptation is of fundamental importance to linking genetic and phenotypic information. This project will enhance the infrastructure for research by continuing to foster partnerships between computational and empirical groups, as well as functional and evolutionary labs.