Novel Platinum and Palladium Reactions Relevant to Hydrocarbon Functionalization

在这个由化学部化学催化项目资助的项目中，华盛顿大学的Karen I. Goldberg教授将对基本的有机金属反应进行详细的机理理解，这些反应可以选择性地切割碳氢键，可以激活分子氧使其成为选择性氧化剂，并且可以通过形成新的碳-碳和碳-氧键来选择性地产生功能化有机产品。这些反应对于研究和理解是至关重要的，因为它们可以应用于对我们社会至关重要的化学品和材料的制造——从塑料和建筑材料，到新的农产品和药品。这些化学物质中的许多都是大规模生产的。但目前的工艺复杂，消耗大量能源和/或产生大量废物。戈德堡教授的努力可能会使化学家们更快、更有选择性地进行反应，使用更少的能量、更少的危险试剂，产生更少的副产物。更广泛的影响包括向高中生、教师和公众推广，以及对本科生和研究生研究人员的培训。这项工作将增强我们对催化过程的基本理解。迫切需要更有效的方法从石油基产品中生产散装化学品。此外，能够激活和选择性地转化烷烃中的C-H键，可以通过提供有效运输和利用天然气储备的新途径，显著影响我们对石油的依赖。

In this project funded by the Chemical Catalysis Program of the Chemistry Division, Professor Karen I. Goldberg of the University of Washington will develop detailed mechanistic understanding of fundamental organometallic reactions that can selectively cleave carbon-hydrogen bonds, can activate molecular oxygen to enable its use as a selective oxidant, and can selectively produce functionalized organic products through the formation of new carbon-carbon and carbon-oxygen bonds. These reactions are vital to study and understand because they can be applied to the manufacturing of chemicals and materials that are essential to our society - from plastics and building supplies, to new agricultural products and pharmaceuticals. Many of these chemicals are produced on huge scales. But the current processes are complex, consume large amounts of energy and/or produce significant waste. Professor Goldberg's efforts may enable chemists to conduct the reactions more quickly and selectively using less energy, using less dangerous reagents, and producing fewer by-products. The broader impacts involve outreach to high school students, teachers, and the general public as well as training of undergraduate and graduate student researchers.This work will enhance our fundamental understanding about catalytic processes. There is a substantial need for more efficient ways of making bulk chemicals from petroleum-based products. In addition, being able to activate and selectively transform C-H bonds in alkanes could significantly impact our dependence on oil by providing new routes to efficiently transport and utilize natural gas reserves.