Catch and Release of Small Molecules With Porous Nanocapsules

大分子、超分子和纳米化学(MSN)计划支持孟菲斯大学Eugene Pinkhassik教授的工作，重点是调节小分子通过门控纳米孔的运输，并创建能够快速摄取和释放小分子的纳米胶囊。运输将通过控制纳米孔的化学环境和可逆的塞子或盖子的结合来调节。具有门控输运的新型纳米薄膜材料将被用于制造适用于现有领域的功能器件，如药物或显像剂的输送以及使新技术成为可能。具有可编程特性的新材料将在生物医学、生物技术和环境应用中发挥作用。能够快速捕捉和释放生物活性分子的设备可能会使诊断和靶向治疗更加有效。这一跨学科项目将研究和培训与针对科学和工程领域代表性不足群体的外联活动结合在一起。

The Macromolecular, Supramolecular and Nanochemistry (MSN) Program supports the work of Professor Eugene Pinkhassik of the University of Memphis focusing on regulating the transport of small molecules through gated nanopores and creating nanocapsules capable of rapid uptake and release of small molecules. The transport will be regulated by controlling chemical environment of nanopores and by reversible binding of plugs or lids. New nanometer-thin materials with gated transport will be used to fabricate functional devices suitable for applications in existing fields such as delivery of drugs or imaging agents and for enabling new technologies.New materials with programmable properties will be useful in biomedical, biotechnology, and environmental applications. Devices capable of rapid catch and release of bioactive molecules are likely to make diagnosis and targeted therapy more efficient. This interdisciplinary project integrates research and training with outreach activities aimed at underrepresented groups in science and engineering.