2010 Gordon Research Conference on Biointerface Science; Les Diablerets, Switzerland; September 5-9, 2010

ID: MPS/DMR/BMAT(7623) 1019376 PI：梅瑟史密斯，菲利普ORG：戈登研究会议标题：2010戈登研究会议生物界面科学知识优点：生物界面科学涉及生物分子与表面相互作用的研究和控制。生物界面现象是生物系统普遍存在的关键特征，也是合成材料与生物系统界面的大多数情况下的关键特征。尽管生物界面现象在理解生物系统中的重要性，但该领域直到最近才开始作为一个独特的跨学科研究领域引起人们的注意。生物界面科学不仅仅是表面科学的一个分支学科；由于生物大分子的独特性质和水的普遍影响，它本身就是一门新的学科。与合成分子相比，生物分子在结构上更大，在结构和活性上往往要复杂得多，而且极其脆弱。这对如何操纵和研究它们造成了严重的限制。生物分子，尤其是蛋白质，很容易在表面吸附、展开和变性，因此在处理和研究它们时必须非常小心。同样，已经开发的在界面上操纵合成分子的方法可能无法用于生物分子相互作用。鉴于生物分子的独特特性以及它们在生物分子接触表面的实际应用中所具有的日益增长的技术重要性，生物界面科学GRC的目标是提供一个论坛，使该领域的最新进展能够在一个有利于参与者互动和讨论的环境中传播。更广泛的影响：与其他GRC一样，生物界面科学GRC旨在汇集多元化的演讲者群体，包括广泛认可的思想领袖以及以其工作的新颖性和质量而闻名的年轻科学家。精心挑选的、充满活力的讨论领导者将对主题领域提供深刻的概述，并组织讨论，吸引不同的与会者。主要目标是促进生物界面科学新思想的跨学科施肥。grc通常在远程环境中举行，是正式演讲、深入讨论和非正式网络的混合体。它们代表了一种理想的机制，将在这一领域工作的化学家、物理学家、生物学家和生物工程师聚集在一起，否则在传统的会议线路上就不会相交。这种形式通过口头和海报会议以及下午休息和晚上社交时间的社会活动等非正式互动，促进了年轻科学家、未被充分代表的少数民族科学家和初级教师与该领域杰出的高级研究人员的互动。8名女性和少数族裔发言人/讨论领袖被列入初步计划。

ID: MPS/DMR/BMAT(7623) 1019376 PI: Messersmith, Phillip ORG: Gordon Research ConferencesTitle: 2010 Gordon Research Conference on Biointerface Science INTELLECTUAL MERIT: Biointerface Science involves the study and control of biomolecular interactions with surfaces. Biointerfacial phenomena are ubiquitous and critical features of biological systems as well as most cases where synthetic materials interface with biological systems. Despite the importance of biointerfacial phenomena in understanding biological systems, the field has only recently begun to attract attention as a unique interdisciplinary area of research. Biointerface Science is not merely a sub-discipline of Surface Science; it is rather a new discipline in its own right, owing to the unique nature of biological macromolecules and the pervasive influence of water. Compared to synthetic molecules, biomolecules are structurally larger, are often significantly more sophisticated in their structure and activity, and are extremely fragile. This places severe constraints on how they can be manipulated and studied. Biomolecules, especially proteins, readily adsorb, unfold and denature at surfaces, so that the utmost care must be taken in handling and studying them at surfaces. Likewise, approaches that have been developed to manipulate synthetic molecules at interfaces may fail for biomolecular interactions. In view of the unique properties of biomolecules and the increasing technological importance that they have assumed in practical applications where biomolecules meet surfaces, the goal of the Biointerface Science GRC is to provide a forum that enables dissemination of the latest advances in the field, in a setting that is conducive to participant interaction and discussion.BROADER IMPACTS: Like other GRCs, the Biointerface Science GRC seeks to bring together a diverse group of speakers that is comprised of widely acknowledged thought-leaders as well as young scientists who are notable for the novelty and quality of their work. Carefully selected, dynamic discussion leaders will provide insightful overview of the topic areas and orchestrate discussions that draw in the diverse group of attendees. A primary goal is to promote cross-disciplinary fertilization of new ideas in Biointerface Science. GRCs are typically held in a remote setting, and are a mixture of formal presentations, in-depth discussion and informal networking. They represent an ideal mechanism to bring together the chemists, physicists, biologists and bioengineers working in this area that would otherwise not intersect on the traditional conference circuit. The format promotes interaction of young scientists, underrepresented minority scientists, and junior faculty with prominent senior investigators in the field through the oral and poster sessions and through informal interactions such as social activities during the afternoon break and evening social hour. Eight women and minority speakers/discussion leaders are included in the preliminary program.