2010 Enzymes, Coenzymes, and Metabolic Pathways Gordon Research Conference in Waterville, NH on July 18-23

2010 年酶、辅酶和代谢途径戈登研究会议于 7 月 18 日至 23 日在新罕布什尔州沃特维尔举行

• 批准号: 0963698
• 负责人: Bruce Palfey
• 金额: $ 0.5万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0963698&HistoricalAwards=false
• 关键词: 2010; Enzymes; Coenzymes; Metabolic; Pathways

Intellectual MeritLife is controlled by chemistry. The thousands of vital chemical reactions that allow life are catalyzed by enzymes. Despite being studied systematically for more than a century, it is still not clear how enzymes accelerate chemical reactions. Enzymology has delved deeply into uncovering the mechanism of catalysis in biology and now attempts to understand reactivity in terms of macromolecular structure and in the dynamic motions of macromolecules. Structures and their movements promote some chemically complex, biologically critical reactions. Just as important, these same structures prevent deleterious side-reactions. The elegant tuning of enzyme reactivity is the result of evolution under selective pressure. Changing environments, or changing metabolic imperatives, cause new enzyme activities to evolve. The task of understanding how enzymes catalyze reactions, how their activity is controlled, and how new activities can emerge requires insight from many perspectives. This Gordon Conference on Enzymes, Coenzymes and Metabolic Pathways will provide a highly interactive venue to present discuss and debate the cutting-edge of enzyme research.Broader ImpactThe Gordon Research Conference (GRC) on Enzymes, Coenzymes and Metabolic Pathways is now one of the most influential in the broad area of enzymology. It gathers the leaders in the field, trainees at the student or postdoctoral level, and those in between. The collegial, informal atmosphere, coupled to the GRC non-disclosure policy, is extremely effective in fostering the free exchange of ideas and cutting-edge results. The Enzymes GRC has truly been the birthplace of many fruitful collaborations and new research directions. The Enzymes GRC has also been a very effective mechanism for incorporating women and underrepresented minorities into enzymology and the metabolic pathway community. The event allows participants to build invaluable networks with leaders in the field from academia, industry, and government. This year's conference continues this tradition of inclusiveness, with a very high proportion of speakers and discussion leaders being women and underrepresented minorities. The conference also provides important networking opportunities and intellectual development for graduate students and postdoctoral associated, and, therefore, helps to sustain the field by developing new talent.

生命是由化学控制的。 生命赖以存在的数千种重要化学反应都是由酶催化的。 尽管人们对酶进行了长达世纪的系统研究，但酶如何加速化学反应仍不清楚。 酶学已经深入地揭示了生物学中的催化机制，现在试图理解大分子结构和大分子动态运动方面的反应性。 结构和它们的运动促进了一些化学复杂的、生物关键的反应。 同样重要的是，这些相同的结构可以防止有害的副反应。 酶反应性的优雅调整是在选择压力下进化的结果。 改变环境，或改变代谢的必要性，导致新的酶活性的演变。 了解酶如何催化反应，它们的活性如何被控制，以及新的活性如何出现，需要从多个角度进行深入研究。本次戈登酶，辅酶和代谢途径会议将提供一个高度互动的场所，目前讨论和辩论酶研究的前沿。更广泛的影响酶，辅酶和代谢途径的戈登研究会议（GRC）现在是酶学领域最有影响力的会议之一。 它聚集了该领域的领导者，学生或博士后水平的受训者，以及介于两者之间的人。 学院式的非正式氛围，加上GRC的保密政策，在促进思想的自由交流和尖端成果方面非常有效。 酶GRC确实是许多富有成效的合作和新研究方向的诞生地。 酶GRC也是一个非常有效的机制，将妇女和代表性不足的少数民族纳入酶学和代谢途径社区。 该活动允许参与者与学术界，工业界和政府领域的领导者建立宝贵的网络。 今年的会议延续了这种包容性的传统，发言者和讨论领导人中有很高比例是妇女和代表性不足的少数群体。 会议还为研究生和博士后提供了重要的网络机会和智力发展，因此，有助于通过培养新的人才来维持该领域。