What are the Next Steps to Mitigate the Threat Posed by Environmental Estrogens? A Workshop Designed to Focus the Field And Provide a Research 2010 Decade, May 2010, Milwaukee WI

主要研究者：Paige Novak提案编号：CBET-1039402鉴于某些雌激素化学品在极低水平（1 ng/L）下的高效力，环境雌激素（EE）可能是人类产生的最危险的污染物。 EE包括天然和合成激素、PPCP、植物性植物雌激素以及一系列工业产品和副产品。 众所周知，在环境相关浓度下，它们会导致鱼类的生殖和行为问题。 现在还知道，我们的地表水中有这些化合物的来源，而这些来源以前被忽视了。 仍然存在的问题是，什么是最相关的环境污染源，它们的最大威胁（对生态系统和人类健康）在哪里，它们在各种环境中的命运是什么，以及在环境灾难发生之前需要做些什么来停止使用和/或向环境排放这些潜在的污染物。 与我们已经面临（滴滴涕）或确实面临（全球气候变化）的许多其他环境挑战不同，这是一个我们有潜力在造成严重损害之前解决的挑战。 为此，我们必须迅速采取行动，将该领域相关科学家和工程师的才能和创造力集中在一系列有凝聚力的研究问题上。 PI计划组织一个为期两天半的研讨会，其成果将是一份将提交给《科学》等知名期刊的论文。 本文将阐述与会者认为这一领域最紧迫的问题，并将作为一种手段，集中和参与更广泛的科学界，希望我们能够更好地解决和努力解决环境雌激素问题，在它对生态系统或人类健康产生重大和广泛的影响之前。 有一个？临界质量？研究人员跨越雌激素的来源，它们的环境命运，以及这些化合物对生态和人类健康的影响。不幸的是，这些研究人员并没有协同工作，在某些领域（命运）工作的人不一定与在其他领域（人类健康影响）工作的人交流。 该领域缺乏领导，没有集中精力解决一系列共同而明确的问题，从而真正解决这一问题。 本次研讨会将集中在一个连贯的研究议程上的环境雌激素领域的工作。 这将使他们能够找到解决雌激素污染问题的真正办法。 这次研讨会的成果将是一份非常公开的文件，但也应该产生更有重点和更高质量的研究。 这将使饮用水和地表水更好地保障人类和生态健康。

Principal Investigator: Paige NovakProposal No: CBET-1039402Given the high potency of some estrogenic chemicals at extremely low levels (1 ng/L), environmental estrogens (EEs) are potentially the most dangerous pollutants that humans produce. EEs include natural and synthetic hormones, PPCPs, plant-based phytoestrogens, and a range of industrial products and byproducts. It is known that they cause reproductive and behavioral problems in fish at environmentally-relevant concentrations. It is also now known that there are sources of these compounds to our surface water that had previously been ignored. Questions remain as to what the most relevant sources of EEs are, where their greatest threat lies (both to ecosystems and to human health), what their fate is in various environments, and what needs to be done to stop the use and/or discharge of these potent pollutants into the environment before an environmental disaster occurs. Unlike many other environmental challenges that we have faced (DDT) or do face (global climate change), this is one that we have the potential to solve before much damage is done. To do so, we must act quickly and focus the talent and creativity of the relevant scientists and engineers in the field on a set of cohesive research questions. The PIs plan to organize a workshop that will span two and a half days, the outcome of which will be a paper that will be submitted to a high-profile journal such as Science. This paper will lay out what the participants feel are the most urgent questions in this field and will act as a means to focus and engage the wider scientific community in the hope that we can better address and work to solve the environmental estrogen problem before it has significant and widespread effects on ecosystems or human health. There is a ?critical mass? of researchers spanning the topics of estrogen sources, their environmental fate, and the ecological and human health effects of these compounds. Unfortunately, these researchers are not working in concert and those working in certain areas (fate) do not necessarily communicate with those working in other areas (human health impacts). The field lacks leadership and is not focused on a common and clear set of questions that will allow it to truly solve this problem. This workshop will focus those working in the field of environmental estrogens on a cohesive research agenda. This will enable them to find a true solution to the problem of estrogen pollution. The outcome of this workshop will be a very public document, but more focused and higher quality research should also result. This will result in drinking water and surface water that better safeguards human and ecological health.