MRI: Development of an NMR Console for the 36 T Series Hybrid

技术摘要核磁共振(核磁共振)控制台的开发是执行科学计划的关键，该计划资助了NHMFL的串联混合磁体。建议的控制台和新的高均质磁体将使高均一核磁共振的可用磁场从23 T增加到36 T，并提供重要的科学机会。科学家将首次能够获得强加宽同位素的化学分辨光谱。这些四极核构成了元素周期表的大部分，对催化剂、多孔材料、电池和燃料电池都很重要，它们对分子电场很敏感，但由于它们的极端谱线展宽，用低场核磁共振进行研究是不现实的。此外，超过25%的生物大分子含有金属。这些原子核也将可以新近被核磁共振探测到。四极物种17^O和14^N是重要的功能活性中心，在36T时可以直接观察到。该控制台还将促进固体材料1H核磁共振分析的新技术的发展，其中共振线因大的自旋相互作用而加宽。通过结合非常高场和非常快速的样品旋转，1H固态核磁共振波谱有望成为一种非常灵敏的工具，具有足够的光谱分辨率，可以应对从功能化硅酸盐表面到大分子研究的各种科学挑战。用户设备提供高达36T的高质量光谱学，将使美国在可预见的未来保持在固态磁共振的前沿。非技术摘要对氢的微弱磁信号的分析导致了我们所知的医学革命，即磁共振成像。核磁共振及其表亲核磁共振(核磁共振)过去的发展已经足够重要，足以获得四项诺贝尔奖。核磁共振使用相同的信号进行化学分析。然而，在所有的元素中，只有一小部分可以在传统的核磁共振扫描仪和核磁共振光谱仪中观察到。其他元素，包括大多数对科学和医学很重要的元素，在实验室通常可以买到的磁铁中只能产生分辨率很差的信号。拟议的核磁共振/核磁共振扫描仪，加上已经在建设中的由国家科学基金会支持的强大的新磁体，将极大地扩大核磁共振研究的元素范围，包括元素周期表的大部分。分析这些元素的化学结构有可能改善许多领域的生活，如电池和燃料电池的开发，以及新催化剂的开发。光谱仪对于执行NSF资助的系列混合磁铁的科学计划是必不可少的，这是一种新的动力研究磁铁，使用的能量更少，并且比以前的动力磁铁具有更均匀和恒定的磁场。创新的磁体和核磁共振光谱仪将成为Mag实验室用户计划的一部分，使美国在可预见的未来保持在磁共振研究的前沿。

Technical AbstractThe development of a nuclear magnetic resonance (NMR) console is essential to carry out the scientific program for which the Series Hybrid magnet at the NHMFL was funded. The proposed console together with the new high homogeneity magnet will increase the available field for high-homogeneity NMR from 23 to 36 T and provide important scientific opportunities. For the first time, scientists will be able to obtain chemically resolved spectra of strongly broadened isotopes. These quadrupolar nuclei, which comprise most of the periodic table and which are important for catalysts, porous materials, batteries and fuel cells, are sensitive to the molecular electric field but are impractical to study by lower field NMR due to their extreme line broadening. In addition, more than 25% of all biological macromolecules contain metals. These nuclei will also be newly accessible to NMR. The quadrupolar species 17^O and 14^N are important sites of functional activity, and will be directly observable at 36 T. The console will also facilitate development of new techniques for 1H NMR analysis of solid materials, in which the resonance lines are broadened by large spin interactions. By combining very high field and very fast sample spinning, 1H solid state NMR spectroscopy promises to become a very sensitive tool with adequate spectral resolution for scientific challenges, ranging from functionalized silicate surfaces to macromolecular studies. The user facility, providing high quality spectroscopy at up to 36 T, will allow the United States to stay at the forefront of solid state magnetic resonance for the foreseeable future.Non-Technical AbstractAnalysis of the weak magnetic signals from hydrogen led to the revolution in medicine that we know as MRI, or Magnetic Resonance Imaging. Past developments in MRI and its first cousin nuclear magnetic resonance (NMR), which uses the same signals for chemical analysis, have been significant enough to garner four Nobel prizes. And yet, of all the elements, only a handful can be observed in conventional MRI scanners and NMR spectrometers. Other elements, including most of those important to science and medicine, produce only poorly resolved signals in the magnets typically available in laboratories. The proposed NMR/MRI scanner, together with a strong new NSF-supported magnet already under construction, will greatly extend the range of elements that can be studied by NMR to include most of the periodic table. Analyzing the chemical configuration of these elements has the potential to improve many areas of life, such as the development of batteries and fuel cells, and of new catalysts. The spectrometer is essential to carry out the scientific program of the NSF-funded series hybrid magnet, a new powered research magnet that uses less energy, and has a more uniform and constant field than previous powered magnets. The innovative magnet and NMR spectrometer will become part of the Mag Lab's user program, allowing the U.S. to stay at the forefront of magnetic resonance research for the foreseeable future.