Foreign DNA is a danger signal for mammalian cells

该项目研究细胞通常如何对外来DNA做出反应，并且与了解身体如何对抗感染，特别是病毒感染有关。 这些结果将帮助我们设计更有效的传染病治疗方法。研究对DNA的反应也将促进自身免疫性疾病狼疮的新治疗方法的设计，并有助于改进将DNA引入细胞或组织的技术或治疗方法。这包括基因治疗、疫苗接种的新策略以及通过生物技术生产蛋白质作为药物。该项目将促进预防性医疗保健、老龄化、高效老龄化、突破性科学和新技术领域的国家研究重点。

This project investigates how cells normally respond to foreign DNA, and is relevant to understanding how the body fights infections, particularly by viruses. The results will help us to design more effective treatments for infectious disease. Studying responses to DNA will also promote the design of new treatments for the autoimmune disease lupus, and help improve technologies or treatments where DNA is introduced into cells or tissues. This includes gene therapy, new strategies for vaccination, and the production of proteins as drugs by biotechnology. The project will promote National Research Priorities in the areas of preventative healthcare, ageing well ageing productively, breakthrough science and new technologies.