RAPID: Collaborative Research: Genetic Impact of the Deepwater Horizon Oil Release

这一快速提案汇集了受深水地平线(DH)漏油影响的州的大学之间的合作。随着数百万加仑石油的释放，分散剂的使用，以及地下石油“大量涌入”到海湾和河口的可能性，可能会对人类和自然人口造成前所未有的人为影响。这项研究将使用墨西哥湾入海口的天然居民巨鳍鱼来确定水解油释放的生理和进化影响。通过应用尖端技术，将描述人类对这一环境影响的遗传效应，从而提供基线数据，以证明石油污染对遗传多样性的影响以及补救措施在限制漏油对生物多样性负面影响方面的有效性。这些数据将向社会通报卫生署漏油事件的短期和长期影响，这在最近的基因组技术创新之前是不可能的。基因组技术的应用提供了对受水解油影响的基因的洞察，以及清理工作是否有效地将遗传多样性的损失降至最低。因此，这项研究应该为BP清理工作的有效性提供证据。此外，通过测量水解油对鱼类基因组学的影响，将收集关于对人类健康至关重要的基因的更多信息。简单地说，通过测量暴露在水解油中的鱼类中存活的基因，可以识别出可能对人类健康也很重要的基因。

This RAPID proposal brings together a collaboration among Universities in states affected by the Deepwater Horizon (DH) oil release. With the millions of gallons of oil released, the use of dispersants and the likelihood of movement of the subsurface oil "bloom" into bays and estuaries, an unprecedented anthropogenic impact on human and natural populations may result. This study will define the physiological and evolutionary impact of the DH oil release using the fish Fundulus grandis, a natural inhabitant of estuaries along the Gulf of Mexico. By applying cutting edge technologies, the genetic effects of man's impact on this environment will be described and, thus, provide the baseline data to document the effect of oil pollution on genetic diversity and effectiveness of remediation in limiting negative biodiversity consequences of the spill. These data will inform society about the short and long-term impacts of the DH oil spill, which has not been possible prior to the recent innovation in genomic techniques. The application of genomic technology provides insights into the genes affected by DH oil and whether cleanup efforts effectively minimize loss of genetic diversity. Thus, this research should provide the evidence of the effectiveness of BP cleanup efforts. Additionally, by measuring the impact of DH oil on fish genomics, additional information will be gathered regarding the genes that matter for human health. Simply put, by measuring the genes in fish that survive exposure to DH oil, genes that may also be important for human health will be identified.